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dc.contributor.author Machado, Ignacio
dc.contributor.author Marino, Leonardo Biancolino
dc.contributor.author Demoro, Bruno
dc.contributor.author Echeverría, Gustavo Alberto
dc.contributor.author Piro, Oscar Enrique
dc.contributor.author Leite, Clarice Q. F.
dc.contributor.author Pavan, Fernando R.
dc.contributor.author Gambino, Dinorah
dc.date.available 2018-01-19T21:39:37Z
dc.date.issued 2014-09
dc.identifier.citation Machado, Ignacio; Marino, Leonardo Biancolino; Demoro, Bruno; Echeverría, Gustavo Alberto; Piro, Oscar Enrique; et al.; Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents; Elsevier Masson; European Journal of Medical Chemistry; 87; 9-2014; 267-273
dc.identifier.issn 0223-5234
dc.identifier.uri http://hdl.handle.net/11336/34047
dc.description.abstract In the search for new therapeutic tools against tuberculosis and to further address the therapeutic potential of pyridine-2-thiol 1-oxide (Hmpo) metal complexes, two new octahedral [MIII(mpo)3] complexes, with M = Ga or Bi, were synthesized and characterized in the solid state and in solution. Attempts to crystallize [GaIII(mpo)3] in CH2Cl2 led to single crystals of the reaction product [GaCl(mpo)2], where the gallium(III) ion is in a square basis pyramidal environment, trans-coordinated at the basis to two pyridine-2-thiolato 1-oxide anions acting as bidentate ligands through their oxygen and sulfur atoms. The biological activity of the new [MIII(mpo)3] complexes together with that of the previously reported Fe(III) analogous compound and the pyridine-2-thiol 1-oxide sodium salt (Na mpo) was evaluated on Mycobacterium tuberculosis. The compounds showed excellent activity, both in the standard strain H37Rv ATCC 27294 (pan-susceptible) and in five clinical isolates that are resistant to the standard first-line anti-tuberculosis drugs isoniazid and rifampicin. These pyridine-2-thiol 1-oxide derivatives are promising compounds for the treatment of resistant tuberculosis.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Masson
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject Gallium complexes
dc.subject Salicylaldehyde semicarbazones
dc.subject ONO donors
dc.subject Anti-tumor
dc.subject Anti-mycobacteria
dc.subject.classification Astronomía
dc.subject.classification Ciencias Físicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.subject.classification Otras Ciencias Químicas
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title Bioactivity of pyridine-2-thiolato-1-oxide metal complexes: Bi(III), Fe(III) and Ga(III) complexes as potent anti-Mycobacterium tuberculosis prospective agents
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-01-18T17:17:53Z
dc.journal.volume 87
dc.journal.pagination 267-273
dc.journal.pais Francia
dc.description.fil Fil: Machado, Ignacio. Universidad de la República; Uruguay
dc.description.fil Fil: Marino, Leonardo Biancolino. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil Fil: Demoro, Bruno. Universidad de la República; Uruguay
dc.description.fil Fil: Echeverría, Gustavo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
dc.description.fil Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
dc.description.fil Fil: Leite, Clarice Q. F.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil Fil: Pavan, Fernando R.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil
dc.description.fil Fil: Gambino, Dinorah. Universidad de la República; Uruguay
dc.journal.title European Journal of Medical Chemistry
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.ejmech.2014.09.067
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0223523414008861
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)