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dc.contributor.author
López León, Micaela
dc.contributor.author
Reggiani, Paula Cecilia
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Hereñú, Claudia Beatriz
dc.contributor.author
Goya, Rodolfo Gustavo
dc.date.available
2018-01-19T21:38:11Z
dc.date.issued
2014-12
dc.identifier.citation
López León, Micaela; Reggiani, Paula Cecilia; Hereñú, Claudia Beatriz; Goya, Rodolfo Gustavo; Regenerative Medicine for the Aging Brain; Enliven; Journal of Stem Cell Research and Regenerative Medicine; 1; 1; 12-2014; 1-9
dc.identifier.issn
2379-5751
dc.identifier.uri
http://hdl.handle.net/11336/34040
dc.description.abstract
In the central nervous system, cholinergic and dopaminergic (DA) neurons are among the cells most susceptible to the deleterious effects of age. Thus, the basal forebrain cholinergic system is known to undergo moderate neurodegenerative changes during normal aging as well as severe atrophy in Alzheimer’s disease (AD). Parkinson’s disease (PD), a degeneration of nigro-striatal DA neurons is the most conspicuous reflection of the vulnerability of DA neurons to age. In this context, cell reprogramming offers novel therapeutic possibilities for the treatment of these devastating diseases. In effect, the generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the overexpression of a few embryonic transcription factors (TF). This discovery fundamentally widened the research horizon in the fields of disease modeling and regenerative medicine. Although it is possible to re-differentiate iPSCs to specific somatic cell types, the tumorigenic potential of contaminating iPSCs that failed to differentiate, increases the risk for clinical application of somatic cells generated by this procedure. Therefore, reprogramming approaches that bypass the pluripotent stem cell state are being explored. A method called lineage reprogramming has been recently documented. It consists of the direct conversion of one adult cell type into another by transgenic expression of multiple lineage-specific TF or microRNAs. Another approach, termed direct reprogramming, features several advantages such as the use of universal TF system and the ability to generate a rejuvenated multipotent progenitor cell population, able to differentiate into specific cell types in response to a specific differentiation factors. These novel approaches offer a new promise for the treatment of pathologies associated with the loss of specific cell types as for instance, nigral DA neurons (in PD) or basal forebrain cholinergic neurons in the early stages of AD. The above topics are reviewed here.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Enliven
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Stem Cells
dc.subject
Reprogramming
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Regenerative Medicine
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Aging Brain
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Regenerative Medicine for the Aging Brain
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-18T17:16:42Z
dc.journal.volume
1
dc.journal.number
1
dc.journal.pagination
1-9
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: López León, Micaela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Reggiani, Paula Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Hereñú, Claudia Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.description.fil
Fil: Goya, Rodolfo Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Bioquímicas de La Plata ; Argentina
dc.journal.title
Journal of Stem Cell Research and Regenerative Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.enlivenarchive.org/articles/regenerative-medicine-for-the-aging-brain.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.enlivenarchive.org/articles/regenerative-medicine-for-the-aging-brain.html
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