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Artículo

Bioadhesive and biocompatible films as wound dressing materials based on a novel dendronized chitosan loaded with ciprofloxacin

García, Mónica CristinaIcon ; Aldana, Ana AgustinaIcon ; Tartara, Luis IgnacioIcon ; Alovero, FabianaIcon ; Strumia, Miriam CristinaIcon ; Manzo, Ruben HilarioIcon ; Martinelli, MarisaIcon ; Jimenez Kairuz, Alvaro FedericoIcon
Fecha de publicación: 11/2017
Editorial: Elsevier
Revista: Carbohydrate Polymers
ISSN: 0144-8617
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Químicas

Resumen

The bioadhesive polymeric films as topical drug delivery systems are interesting alternatives to improve the pharmacotherapy and patient compliances. New derivate biomaterials based on weisocyanate- dendronized PVP- crosslinked chitosan and loaded with ciprofloxacin (CIP), as model drug, were used to prepare bioadhesive films. Relevant in vitro/in vivo attributes to define main physicochemical and biopharmaceutical characteristics for topical wound-healing applications were evaluated. A high proportion of CIP, uniformly dispersed along throughout the film, was loaded. An extended release of CIP and different behaviors of release profiles, depending on the presence of dendron, were observed. The films loaded with CIP were effective in inhibiting the growth of both Gram positive and Gram negative bacteria. In addition, biocompatibility and bioadhesion into conjuntival-sacs of the rabbits suggests that these films have good properties to be applied over skin wounds for topical applications, allowing a reduction of the frequency of administration and improving the residence time of the films.
Palabras clave: Dendronized Chitosan , Ciprofloxacin , Biocompatible Materials , Bioadhesive Film , Topical Administration , Drug Controlled Release
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/33773
DOI: http://dx.doi.org/10.1016/j.carbpol.2017.07.053
URL: http://www.sciencedirect.com/science/article/pii/S0144861717308305
Colecciones
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos(IPQA)
Articulos deINSTITUTO DE INVESTIGACION Y DESARROLLO EN INGENIERIA DE PROCESOS Y QUIMICA APLICADA
Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
García, Mónica Cristina; Aldana, Ana Agustina; Tartara, Luis Ignacio; Alovero, Fabiana; Strumia, Miriam Cristina; et al.; Bioadhesive and biocompatible films as wound dressing materials based on a novel dendronized chitosan loaded with ciprofloxacin; Elsevier; Carbohydrate Polymers; 175; 11-2017; 75-86
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