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dc.contributor.author
Narayanaswamy, Venugopala K.
dc.contributor.author
Gleiser, Raquel M.
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Chalannavar, Raju K.
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Odhav, Bharti
dc.date.available
2018-01-18T14:34:00Z
dc.date.issued
2014-03
dc.identifier.citation
Narayanaswamy, Venugopala K.; Gleiser, Raquel M.; Chalannavar, Raju K.; Odhav, Bharti; Antimosquito Properties of 2-Substituted Phenyl/benzylamino-6-(4- chlorophenyl)-5-methoxycarbonyl-4-methyl-3,6-dihydropyrimidin-1-ium Chlorides Against Anopheles arabiensis; Bentham Science Publishers; Medicinal Chemistry; 10; 2; 3-2014; 211-219
dc.identifier.issn
1573-4064
dc.identifier.uri
http://hdl.handle.net/11336/33766
dc.description.abstract
Eight novel dihydropyrimidine analogs named DHPM1-DHPM8 was synthesized in their hydrochloride salt form using one pot synthesis between methyl 2-chloro-4-(4-chlorophenyl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate and substituted arylamines in isopropanol. The antimosquito effect of the test compounds were assessed against the adult mosquito Anopheles arabiensis. For adulticidal properties the test compounds were sprayed onto ceramic tiles and screened using the cone bio-assay method. The larvicidal activity was tested by monitoring larval mortality daily and up to 3 days of exposure. Repellency properties were tested in a feeding-probe assay using unfed female Anopheles arabiensis. Compounds DHPM1, DHPM4, DHPM5 and DHPM6 exerted larval mortality equivalent to temephos (trade name Abate, a commercial larvicidal compound). Compounds DHPM1 to DHPM5 repelled or knocked down 92 to 98% of mosquitoes exposed to rodent skin treated with the compounds. None of the compounds showed any significant activity against the adult mosquito Anopheles arabiensis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Bentham Science Publishers
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adulticidal
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Anopheles Arabiensis
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Dihydropyrimidines
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Antimosquito
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Larvicidal
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Repellency
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antimosquito Properties of 2-Substituted Phenyl/benzylamino-6-(4- chlorophenyl)-5-methoxycarbonyl-4-methyl-3,6-dihydropyrimidin-1-ium Chlorides Against Anopheles arabiensis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-17T15:01:13Z
dc.journal.volume
10
dc.journal.number
2
dc.journal.pagination
211-219
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oak Park
dc.description.fil
Fil: Narayanaswamy, Venugopala K.. Durban University of Technology; Sudáfrica
dc.description.fil
Fil: Gleiser, Raquel M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinar de Biología Vegetal (p). Grupo Vinculado Centro de Relevamiento y Evaluacion de Recursos Agricolas y Naturales; Argentina
dc.description.fil
Fil: Chalannavar, Raju K.. Durban University of Technology; Sudáfrica
dc.description.fil
Fil: Odhav, Bharti. Durban University of Technology; Sudáfrica
dc.journal.title
Medicinal Chemistry
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.2174/157340641002140131164945
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/120122/article
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