Epstein Barr Virus (EBV) Association and Latency Profile in Paediatric Burkitt Lymphoma: Experience of a Single Institution in Argentina

The aim of this study is to characterise EBV expression and latency pattern in paediatric Burkitt lymphoma in a single institution in Argentina. EBV-encoded RNA or protein was analyzed in 27 patients. EBERs was expressed in 37% of patients (29% of immunocompetent and 100% of immunosuppressed patients). EBV-positive cases were observed exclusively in patients younger than 5 years old. EBV association with immunocompetent patients exhibits the sporadic pattern in region under study, while its presence in patients infected with HIV was higher than described previously. EBV latency I profile was present in most of the patients, except for 2 immunosuppressed patients who displayed LMP1 expression.

Palabras clave: Bhrf1 , Ebv , Lmp1 , Childhood , Latency , Lymphoma

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Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)

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URI: http://hdl.handle.net/11336/33488

URL: http://onlinelibrary.wiley.com/doi/10.1002/jmv.23737/abstract

DOI: http://dx.doi.org/10.1002/jmv.23737

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Articulos(SEDE CENTRAL)
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Citación

de Matteo, Elena Noemí; Lara, María Julia; Preciado, María Victoria; Cohen, Melina; Chabay, Paola Andrea; Aversa, Luis; et al.; Epstein Barr Virus (EBV) Association and Latency Profile in Paediatric Burkitt Lymphoma: Experience of a Single Institution in Argentina; Wiley; Journal of Medical Virology; 86; 5; 9-2013; 845-850

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