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dc.contributor.author
Meier, Dominik
dc.contributor.author
Rumbo, Martín
dc.contributor.author
Gondolesi, Gabriel Eduardo
dc.date.available
2018-01-16T19:27:11Z
dc.date.issued
2014-05
dc.identifier.citation
Meier, Dominik; Rumbo, Martín; Gondolesi, Gabriel Eduardo; Current Status of Allograft Tolerance in Intestinal Transplantation; Taylor & Francis; International Reviews of Immunology; 33; 3; 5-2014; 245-260
dc.identifier.issn
0883-0185
dc.identifier.uri
http://hdl.handle.net/11336/33487
dc.description.abstract
Solid organ transplantation has become a clinical practice after the development of different immunosuppressive drugs that allowed controlling rejection. The price to be paid for that is the permanent risk of infections and malignancies and a significant drug-associated toxicity. The establishment of transplant tolerance has been the “holy grail” for transplantation medicine since its beginnings. Different experimental approaches and clinical trials resulted in the accumulation of knowledge on mechanisms and strategies that favor the establishment of tolerance without achieving the objective of autonomous allograft tolerance in the clinical field. Development of tolerance in intestinal transplantation constitutes a challenging situation due to several particular features that contribute to the generation of a strong allogeneic response. In the present review, we summarize the different immune mechanisms that may contribute to allograft tolerance. The different barriers that should be bypassed in intestinal transplantation to tolerate the graft are discussed. Finally, we revise the strategies that were applied with different degrees of success in the clinical field including the most promising recent approaches and the forthcoming candidates in the field that might be translated into clinical trials in the near future.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Taylor & Francis
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Adoptive Cellular Therapy
dc.subject
Chimerism
dc.subject
Operational Tolerance
dc.subject
Rejection
dc.subject
Small Bowel
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Current Status of Allograft Tolerance in Intestinal Transplantation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-16T18:04:53Z
dc.identifier.eissn
1563-5244
dc.journal.volume
33
dc.journal.number
3
dc.journal.pagination
245-260
dc.journal.pais
Reino Unido
dc.journal.ciudad
Londres
dc.description.fil
Fil: Meier, Dominik. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Favaloro; Argentina
dc.description.fil
Fil: Rumbo, Martín. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Ciencias Biológicas. Laboratorio de Investigaciones del Sistema Inmune; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gondolesi, Gabriel Eduardo. Fundación Favaloro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
International Reviews of Immunology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.3109/08830185.2013.829468
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3109/08830185.2013.829468
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