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Artículo

Antimicrobial Activity of Starch Hydrogel Incorporated with Copper Nanoparticles

Villanueva, María EmiliaIcon ; Diez, Ana Maria del Rosario; Gonzalez, Joaquín Antonio; Pérez, Claudio JavierIcon ; Orrego, Manuel; Piehl, Lidia Leonor; Teves, Sergio; Copello, Guillermo JavierIcon
Fecha de publicación: 06/2016
Editorial: American Chemical Society
Revista: Acs Applied Materials & Interfaces
ISSN: 1944-8244
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Biotecnología Industrial

Resumen

In order to obtain an antimicrobial gel, a starch-based hydrogel reinforced with silica-coated copper nanoparticles (Cu NPs) was developed. Cu NPs were synthesized by use of a copper salt and hydrazine as a reducing agent. In order to enhance Cu NP stability over time, they were synthesized in a starch medium followed by a silica coating. The starch hydrogel was prepared by use of urea and water as plasticizers and it was treated with different concentrations of silica-coated copper nanoparticles (Si−Cu NPs). The obtained materials were characterized by Fourier transform infrared (FT-IR) spectroscopy, electron paramagnetic resonance (EPR) spectroscopy, scanning electron microscopy (SEM), and rheometry. FT-IR and EPR spectra were used for characterization of Cu NPs and Si−Cu NPs, confirming that a starch cap was formed around the Cu NP and demonstrating the stability of the copper nanoparticle after the silica coating step. SEM images showed Cu NP, Si−Cu NP, and hydrogel morphology. The particle size was polydisperse and the structure of the gels changed along with particle concentration. Increased NP content led to larger pores in starch structure. These results were in accordance with the rheological behavior, where reinforcement by the Si−Cu NP was seen. Antimicrobial activity was evaluated against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial species. The hydrogels were demonstrated to maintain antimicrobial activity for at least four cycles of use. A dermal acute toxicity test showed that the material could be scored as slightly irritant, proving its biocompatibility. With these advantages, it is believed that the designed Si−Cu NP loaded hydrogel may show high potential for applications in various clinical fields, such as wound dressings and fillers.
Palabras clave: Starch Hydrogel , Copper Nanoparticles , Wound Dressing , Antimicrobial Material
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/33468
URL: http://pubs.acs.org/doi/abs/10.1021/acsami.6b02955
DOI: http://dx.doi.org/10.1021/acsami.6b02955
Colecciones
Articulos(INTEMA)
Articulos de INST.DE INV.EN CIENCIA Y TECNOL.MATERIALES (I)
Articulos(IQUIMEFA)
Articulos de INST.QUIMICA Y METABOLISMO DEL FARMACO (I)
Citación
Teves, Sergio; Pérez, Claudio Javier; Orrego, Manuel; Copello, Guillermo Javier; Villanueva, María Emilia; Piehl, Lidia Leonor; et al.; Antimicrobial Activity of Starch Hydrogel Incorporated with Copper Nanoparticles; American Chemical Society; Acs Applied Materials & Interfaces; 8; 25; 6-2016; 16280-16288
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