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dc.contributor.author
Kang Miller, Jae Eun
dc.contributor.author
Granados Fuentes, Daniel
dc.contributor.author
Wang, Thomas
dc.contributor.author
Marpegan, Luciano
dc.contributor.author
Holy, Timothy E.
dc.contributor.author
Herzog, Erik D.
dc.date.available
2018-01-16T17:11:39Z
dc.date.issued
2014-04
dc.identifier.citation
Herzog, Erik D.; Kang Miller, Jae Eun; Holy, Timothy E.; Wang, Thomas; Granados Fuentes, Daniel; Marpegan, Luciano; et al.; Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction; Society for Neuroscience; Journal of Neuroscience; 34; 17; 4-2014; 6040-6046
dc.identifier.issn
0270-6474
dc.identifier.uri
http://hdl.handle.net/11336/33417
dc.description.abstract
Accumulating evidence suggests that the olfactory bulbs (OBs) function as an independent circadian system regulating daily rhythms in olfactory performance. However, the cells and signals in the olfactory system that generate and coordinate these circadian rhythms are unknown. Using real-time imaging of gene expression, we found that the isolated olfactory epithelium and OB, but not the piriform cortex, express similar, sustained circadian rhythms in PERIOD2 (PER2). In vivo, PER2 expression in the OB of mice is circadian, approximately doubling with a peak around subjective dusk. Furthermore, mice exhibit circadian rhythms in odor detection performance with a peak at approximately subjective dusk. We also found that circadian rhythms in gene expression and odor detection performance require vasoactive intestinal polypeptide (VIP) or its receptor VPAC2R. VIP is expressed, in a circadian manner, in interneurons in the external plexiform and periglomerular layers, whereas VPAC2R is expressed in mitral and external tufted cells in the OB. Together, these results indicate that VIP signaling modulates the output from the OB to maintain circadian rhythms in the mammalian olfactory system.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Society for Neuroscience
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Vip
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Circadian
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Clock
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Olfaction
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Olfactory Discrimination
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Rhythms
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Inmunología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Vasoactive Intestinal Polypeptide Mediates Circadian Rhythms in Mammalian Olfactory Bulb and Olfaction
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-11T13:47:00Z
dc.journal.volume
34
dc.journal.number
17
dc.journal.pagination
6040-6046
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington, DC
dc.description.fil
Fil: Kang Miller, Jae Eun. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Granados Fuentes, Daniel. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Wang, Thomas. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Marpegan, Luciano. Washington University in St. Louis; Estados Unidos. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Holy, Timothy E.. Washington University in St. Louis; Estados Unidos
dc.description.fil
Fil: Herzog, Erik D.. Washington University in St. Louis; Estados Unidos
dc.journal.title
Journal of Neuroscience
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996221/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1523/JNEUROSCI.4713-13.2014
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.jneurosci.org/content/34/17/6040.long
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