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Artículo

Genotyping Mycobacterium bovis from cattle in the Central Pampas of Argentina: temporal and regional trends

Shimizu, Ernesto; Macías, Analía; Paolicchi, Fernando Alberto; Magnano, Gabriel; Zapata, Laura; Fernández, Analía; Canal, Ana; Garbaccio, Sergio; Cataldi, Ángel AdriánIcon ; Caimi, Karina CynthiaIcon ; Zumárraga, Martín JoséIcon
Fecha de publicación: 04/2014
Editorial: Fundação Oswaldo Cruz
Revista: Memórias do Instituto Oswaldo Cruz
ISSN: 0074-0276
e-ISSN: 1678-8060
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Veterinarias

Resumen

Mycobacterium bovis is the causative agent of bovine tuberculosis (TB), a disease that affects approximately 5% of Argentinean cattle. Among the molecular methods for genotyping, the most convenient are spoligotyping and variable number of tandem repeats (VNTR). A total of 378 samples from bovines with visible lesions consistent with TB were collected at slaughterhouses in three provinces, yielding 265 M. bovisspoligotyped isolates, which were distributed into 35 spoligotypes. In addition, 197 isolates were also typed by the VNTR method and 54 combined VNTR types were detected. There were 24 clusters and 27 orphan types. When both typing methods were combined, 98 spoligotypes and VNTR types were observed with 27 clusters and 71 orphan types. By performing a meta-analysis with previous spoligotyping results, we identified regional and temporal trends in the population structure of M. bovis. For SB0140, the most predominant spoligotype in Argentina, the prevalence percentage remained high during different periods, varying from 25.5-57.8% (1994-2011). By contrast, the second and third most prevalent spoligotypes exhibited important fluctuations. This study shows that there has been an expansion in ancestral lineages as demonstrated by spoligotyping. However, exact tandem repeat typing suggests dynamic changes in the clonal population of this microorganism.
Palabras clave: Bovine Tb , Mycobacterium Bovis , Spoligotype , Vntrs
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
Identificadores
URI: http://hdl.handle.net/11336/33394
DOI: http://dx.doi.org/10.1590/0074-0276140292
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015263/
URL: http://ref.scielo.org/4fmzr7
URL: http://memorias.ioc.fiocruz.br/issues/past-issues/item/1641-0292_genotyping-myco
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Cataldi, Ángel Adrián; Caimi, Karina Cynthia; Shimizu, Ernesto; Zumárraga, Martín José; Fernández, Analía; Magnano, Gabriel; et al.; Genotyping Mycobacterium bovis from cattle in the Central Pampas of Argentina: temporal and regional trends; Fundação Oswaldo Cruz; Memórias do Instituto Oswaldo Cruz; 109; 2; 4-2014; 236-245
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