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dc.contributor.author
León Vargas, Fabián
dc.contributor.author
Garelli, Fabricio
dc.contributor.author
de Battista, Hernán
dc.contributor.author
Vehí, Josep
dc.date.available
2018-01-15T18:17:23Z
dc.date.issued
2014-11
dc.identifier.citation
de Battista, Hernán; Garelli, Fabricio; León Vargas, Fabián; Vehí, Josep; Postprandial response improvement via safety layer in closed-loop blood glucose controllers; Elsevier; Biomedical Signal Processing and Control; 16; 11-2014; 80-87
dc.identifier.issn
1746-8094
dc.identifier.uri
http://hdl.handle.net/11336/33271
dc.description.abstract
Traditional type 1 diabetes therapies are prone to show poor glucose regulation especially in the postprandial period owing to both physiological and technological limitations. Although a closed-loop controller for glucose regulation has to be tuned to minimize the postprandial excursion and avoid late hypoglycemia, the intrinsic limitations of the problem lead to a trade-off between postprandial peak and late hypoglycemia risk. This paper reveals through an intensive in-silico study with multiple controller tuning combinations that a novel safety layer for glucose controllers, the so-called SAFE loop (Revert et al., 2013), not only reduces the hypoglycemia events but also allows reducing the postprandial glucose excursion, thus breaking the implicit trade-off present in single controllers. The SAFE outer loop monitors the estimated amount of insulin on board, and modifies the control action if it is close to a unique constraint which can be adjusted with clinical criteria. A very challenging test scenario is here implemented including the rate of blood glucose appearance from intakes of mixed meals, diurnal and day-to-day time-varying metabolic changes, inherent drawbacks in sensor and actuator, and other realistic conditions. The results show a significant reduction of hypoglycemia events when SAFE is added, regardless the closed-loop glucose controller, together with a potential postprandial response improvement.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Artificial Pancreas
dc.subject
Glucose Control
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Hypoglycemia
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Insulin-On-Board
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Constrained Control
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Postprandial
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Sliding Mode Control
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Safety Layer
dc.subject.classification
Ingeniería de Sistemas y Comunicaciones
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Ingeniería Eléctrica, Ingeniería Electrónica e Ingeniería de la Información
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Postprandial response improvement via safety layer in closed-loop blood glucose controllers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-15T17:36:32Z
dc.journal.volume
16
dc.journal.pagination
80-87
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: León Vargas, Fabián. Universidad Antonio Nariño; Colombia
dc.description.fil
Fil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
dc.description.fil
Fil: de Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
dc.description.fil
Fil: Vehí, Josep. Universidad de Girona; España
dc.journal.title
Biomedical Signal Processing and Control
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.bspc.2014.10.003
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1746809414001529
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