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Artículo

Dendritic cells regulate angiogenesis associated with liver fibrogenesis

Blois, Sandra M.; Piccioni, Flavia ValeriaIcon ; Freitag, Nancy; Tirado González, Irene; Moschansky, Petra; Lloyd, Rodrigo; Hensel Wiegel, Karin; Rose, Matthias; García, Mariana GabrielaIcon ; Alaniz, Laura DanielaIcon ; Mazzolini Rizzo, Guillermo DanielIcon
Fecha de publicación: 09/2013
Editorial: Springer
Revista: Angiogenesis
ISSN: 0969-6970
e-ISSN: 1573-7209
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular

Resumen

During liver fibrogenesis the immune response and angiogenesis process are fine-tuned resulting in activation of hepatic stellate cells that produce an excess of extracellular matrix proteins. Dendritic cells (DC) play a central role modulating the liver immunity and have recently been implicated to favour fibrosis regression; although their ability to influence the development of fibrogenesis is unknown. Therefore, we explored whether the depletion of DC during early stages of liver injury has an impact in the development of fibrogenesis. Using the CD11c.DTR transgenic mice, DC were depleted in two experimental models of fibrosis in vivo. The effect of anti-angiogenic therapy was tested during early stages of liver fibrogenesis. DC depletion accelerates the development of fibrosis and as a consequence, the angiogenesis process is boosted. We observed up-regulation of pro-angiogenic factors together with an enhanced vascular endothelial growth factor (VEGF) bioavailability, mainly evidenced by the decrease of anti-angiogenic VEGF receptor 1 (also known as sFlt-1) levels. Interestingly, fibrogenesis process enhanced the expression of Flt-1 on hepatic DC and administration of sFlt-1 was sufficient to abrogate the acceleration of fibrogenesis upon DC depletion. Thus, DC emerge as novel players during the development of liver fibrosis regulating the angiogenesis process and thereby influencing fibrogenesis.
Palabras clave: Dendritic Cells , Angiogenesis , Liver Fibrogenesis , Sflt-1
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/33109
URL: https://link.springer.com/article/10.1007/s10456-013-9382-5
DOI: http://dx.doi.org/10.1007/s10456-013-9382-5
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Citación
Blois, Sandra M.; Piccioni, Flavia Valeria; Freitag, Nancy; Tirado González, Irene; Moschansky, Petra; et al.; Dendritic cells regulate angiogenesis associated with liver fibrogenesis; Springer; Angiogenesis; 17; 1; 9-2013; 119-128
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