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Artículo

Human pegivirus molecular epidemiology in Argentina: Potential contribution of Latin American migration to genotype 3 circulation

Trinks, JulietaIcon ; Maestri, Miriam; Oliveto, Fabián; del Pino, Noemí; Weissenbacher, Mercedes CrecenciaIcon ; Torres, Oscar Walter; Oubiña, Jose RaulIcon
Fecha de publicación: 03/2014
Editorial: Wiley
Revista: Journal of Medical Virology
ISSN: 0146-6615
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

In order to determine the human pegivirus (HPgV) genotypic diversity in Argentina taking into account the potential contribution of human migration from neighboring countries, samples from 130 Argentine injecting drug users, 116 Argentine- and 50 immigrant-pregnant women were analyzed. HPgV RNA prevalence among human immunodeficiency virus (HIV)-positive injecting drug users was similar to HIV-positive pregnant women, as was the case when comparing HIV-negative injecting drug users and HIV-negative pregnant women (P > 0.05). HPgV genotype 2 (HPgV/2) was prevalent among both Argentine injecting drug users and pregnant women, in contrast to HPgV/3 observed among pregnant women from Latin American countries with predominant indigenous populations and who had experienced their initial sexual intercourses––and possibly their source of infection––in those countries (P < 0.01). In addition, HPgV vertical and horizontal transmission was proven by molecular analysis of E2 gene and construction of identity matrixes with epidemiologically non-related isolates. This study shows that human migration from neighboring Latin American countries with predominant indigenous populations might contribute to HPgV/3 circulation in Argentina.
Palabras clave: Gbv-C , Argentina , Viral Genotypes , Immigrants , Human Pegivirus , Injecting Drug Users , Pregnant Women
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/33062
DOI: http://dx.doi.org/10.1002/jmv.23918
URL: http://onlinelibrary.wiley.com/doi/10.1002/jmv.23918/abstract
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Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Oubiña, Jose Raul; del Pino, Noemí; Oliveto, Fabián; Torres, Oscar Walter; Maestri, Miriam; Weissenbacher, Mercedes Crecencia; et al.; Human pegivirus molecular epidemiology in Argentina: Potential contribution of Latin American migration to genotype 3 circulation; Wiley; Journal of Medical Virology; 86; 12; 3-2014; 2076-2083
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