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dc.contributor.author
Yeh, So Wei
dc.contributor.author
Liu, Jen Wei
dc.contributor.author
Yu, Sung Huan
dc.contributor.author
Yih, Chien Hua
dc.contributor.author
Hwang, Jenn Kang
dc.contributor.author
Echave, Julián
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dc.date.available
2018-01-11T14:12:33Z
dc.date.issued
2013-10
dc.identifier.citation
Yeh, So Wei; Liu, Jen Wei; Yu, Sung Huan; Yih, Chien Hua; Hwang, Jenn Kang; et al.; Site-Specific Structural Constraints on Protein Sequence Evolutionary Divergence: Local Packing Density versus Solvent Exposure; Oxford University Press; Molecular Biology and Evolution; 31; 1; 10-2013; 135-139
dc.identifier.issn
0737-4038
dc.identifier.uri
http://hdl.handle.net/11336/32948
dc.description.abstract
Protein sequences evolve under selection pressures imposed by functional and biophysical requirements, resulting in site-dependent rates of amino acid substitution. Relative solvent accessibility (RSA) and local packing density (LPD) have emerged as the best candidates to quantify structural constraint. Recent research assumes that RSA is the main determinant of sequence divergence. However, it is not yet clear which is the best predictor of substitution rates. To address this issue, we compared RSA and LPD with site-specific rates of evolution for a diverse data set of enzymes. In contrast with recent studies, we found that LPD measures correlate better than RSA with evolutionary rate. Moreover, the independent contribution of RSA is minor. Taking into account that LPD is related to backbone flexibility, we put forward the possibility that the rate of evolution of a site is determined by the ease with which the backbone deforms to accommodate mutations.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Protein Evolution
dc.subject
Local Packing Density
dc.subject
Relative Solvent Accessibility
dc.subject
Evolutionary Rate
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Weighted Contact Number
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Contact Number
dc.subject
Protein Structure
dc.subject.classification
Otras Ciencias Químicas
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dc.subject.classification
Ciencias Químicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Site-Specific Structural Constraints on Protein Sequence Evolutionary Divergence: Local Packing Density versus Solvent Exposure
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-08T19:46:10Z
dc.identifier.eissn
1537-1719
dc.journal.volume
31
dc.journal.number
1
dc.journal.pagination
135-139
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Oxford
dc.description.fil
Fil: Yeh, So Wei. National Chiao Tung University; China
dc.description.fil
Fil: Liu, Jen Wei. National Chiao Tung University; China
dc.description.fil
Fil: Yu, Sung Huan. National Chiao Tung University; China
dc.description.fil
Fil: Yih, Chien Hua. National Chiao Tung University; China
dc.description.fil
Fil: Hwang, Jenn Kang. National Chiao Tung University; China
dc.description.fil
Fil: Echave, Julián. Universidad Nacional de San Martín. Escuela de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Molecular Biology and Evolution
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/mbe/article/31/1/135/1048166
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1093/molbev/mst178
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