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dc.contributor.author
Quinteros, Daniela Alejandra
dc.contributor.author
Vicario de la Torre, Marta
dc.contributor.author
Andrés Guerrero, Vanessa
dc.contributor.author
Palma, Santiago Daniel
dc.contributor.author
Allemandi, Daniel Alberto
dc.contributor.author
Herrero Vanrell, Rocío
dc.contributor.author
Molina Martinez, Irene T.
dc.date.available
2018-01-10T21:59:00Z
dc.date.issued
2014-10
dc.identifier.citation
Molina Martinez, Irene T.; Herrero Vanrell, Rocío; Vicario de la Torre, Marta; Andrés Guerrero, Vanessa; Quinteros, Daniela Alejandra; Palma, Santiago Daniel; et al.; Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes; Public Library of Science; Plos One; 9; 10; 10-2014; 1-10; e110344
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/32931
dc.description.abstract
For the treatment of chronic ocular diseases such as glaucoma, continuous instillations of eye drops are needed. However, frequent administrations of hypotensive topical formulations can produce adverse ocular surface effects due to the active substance or other components of the formulation, such as preservatives or other excipients. Thus the development of unpreserved formulations that are well tolerated after frequent instillations is an important challenge to improve ophthalmic chronic topical therapies. Furthermore, several components can improve the properties of the formulation in terms of efficacy. In order to achieve the mentioned objectives, we have developed formulations of liposomes (150–200 nm) containing components similar to those in the tear film and loaded with the hypotensive melatonin analog 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT, 100 µM). These formulations were combined with mucoadhesive (sodium hyaluronate or carboxymethylcellulose) or amphiphilic block thermosensitive (poloxamer) polymers to prolong the hypotensive efficacy of the drug. In rabbit eyes, the decrease of intraocular pressure with 5-MCA-NAT-loaded liposomes that were dispersed with 0.2% sodium hyaluronate, 39.1±2.2%, was remarkably higher compared to other liposomes formulated without or with other bioadhesive polymers, and the effect lasted more than 8 hours. According to the results obtained in the present work, these technological strategies could provide an improved modality for delivering therapeutic agents in patients with glaucoma.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Liposomas
dc.subject
5-Mca-Nat
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Glaucoma
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Polimeros Bioadhesivos
dc.subject.classification
Nano-materiales
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Nanotecnología
dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
dc.title
Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-03T20:10:39Z
dc.journal.volume
9
dc.journal.number
10
dc.journal.pagination
1-10; e110344
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Quinteros, Daniela Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Vicario de la Torre, Marta. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Andrés Guerrero, Vanessa. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Herrero Vanrell, Rocío. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Molina Martinez, Irene T.. Universidad Complutense de Madrid; España
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0110344
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110344


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