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dc.contributor.author Quinteros, Daniela Alejandra
dc.contributor.author Vicario de la Torre, Marta
dc.contributor.author Andrés Guerrero, Vanessa
dc.contributor.author Palma, Santiago Daniel
dc.contributor.author Allemandi, Daniel Alberto
dc.contributor.author Herrero Vanrell, Rocío
dc.contributor.author Molina Martinez, Irene T.
dc.date.available 2018-01-10T21:59:00Z
dc.date.issued 2014-10
dc.identifier.citation Molina Martinez, Irene T.; Herrero Vanrell, Rocío; Vicario de la Torre, Marta; Andrés Guerrero, Vanessa; Quinteros, Daniela Alejandra; Palma, Santiago Daniel; et al.; Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes; Public Library of Science; Plos One; 9; 10; 10-2014; 1-10; e110344
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/11336/32931
dc.description.abstract For the treatment of chronic ocular diseases such as glaucoma, continuous instillations of eye drops are needed. However, frequent administrations of hypotensive topical formulations can produce adverse ocular surface effects due to the active substance or other components of the formulation, such as preservatives or other excipients. Thus the development of unpreserved formulations that are well tolerated after frequent instillations is an important challenge to improve ophthalmic chronic topical therapies. Furthermore, several components can improve the properties of the formulation in terms of efficacy. In order to achieve the mentioned objectives, we have developed formulations of liposomes (150–200 nm) containing components similar to those in the tear film and loaded with the hypotensive melatonin analog 5-methoxycarbonylamino-N-acetyltryptamine (5-MCA-NAT, 100 µM). These formulations were combined with mucoadhesive (sodium hyaluronate or carboxymethylcellulose) or amphiphilic block thermosensitive (poloxamer) polymers to prolong the hypotensive efficacy of the drug. In rabbit eyes, the decrease of intraocular pressure with 5-MCA-NAT-loaded liposomes that were dispersed with 0.2% sodium hyaluronate, 39.1±2.2%, was remarkably higher compared to other liposomes formulated without or with other bioadhesive polymers, and the effect lasted more than 8 hours. According to the results obtained in the present work, these technological strategies could provide an improved modality for delivering therapeutic agents in patients with glaucoma.
dc.format application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.rights info:eu-repo/semantics/openAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject Liposomas
dc.subject 5-MCA-NAT
dc.subject Glaucoma
dc.subject Polimeros Bioadhesivos
dc.subject.classification Nano-materiales
dc.subject.classification Nanotecnología
dc.subject.classification INGENIERÍAS Y TECNOLOGÍAS
dc.title Hybrid Formulations of Liposomes and Bioadhesive Polymers Improve the Hypotensive Effect of the Melatonin Analogue 5-MCA-NAT in Rabbit Eyes
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2018-01-03T20:10:39Z
dc.journal.volume 9
dc.journal.number 10
dc.journal.pagination 1-10; e110344
dc.journal.pais Estados Unidos
dc.journal.ciudad San Francisco
dc.description.fil Fil: Quinteros, Daniela Alejandra. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Vicario de la Torre, Marta. Universidad Complutense de Madrid; España
dc.description.fil Fil: Andrés Guerrero, Vanessa. Universidad Complutense de Madrid; España
dc.description.fil Fil: Palma, Santiago Daniel. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Allemandi, Daniel Alberto. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil Fil: Herrero Vanrell, Rocío. Universidad Complutense de Madrid; España
dc.description.fil Fil: Molina Martinez, Irene T.. Universidad Complutense de Madrid; España
dc.journal.title Plos One
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0110344
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0110344
dc.conicet.fuente unificacion


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  • Articulos(UNITEFA) [130]
    Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA

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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)