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Artículo

Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress

Gonzalez, Paula NataliaIcon ; Lotto, Federico PabloIcon ; Hallgrimsson, Benedikt
Fecha de publicación: 08/2014
Editorial: Wiley-liss, Div John Wiley & Sons Inc
Revista: American Journal Of Physical Anthropology
ISSN: 0002-9483
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Nutritional imbalance is one of themain sources of stress in both extant and extinct humanpopulations. Restricted availability of nutrients isthought to disrupt the buffering mechanisms that con-tribute to developmental stability and canalization,resulting in increased levels of fluctuating asymmetry(FA) and phenotypic variance among individuals. How-ever, the literature is contradictory in this regard. Thisstudy assesses the effect of prenatal nutritional stresson FA and among-individual variance in cranial shapeand size using a mouse model of maternal proteinrestriction. Two sets of landmark coordinates were digi-tized in three dimensions from skulls of control and pro-tein restricted specimens at E17.5 and E18.5. We foundthat, by the end of gestation, maternal protein restric-tion resulted in a significant reduction of skull size.Fluctuating asymmetry in size and shape exceeded theamount of measurement error in all groups, but no sig-nificant differences in the magnitude of FA were foundbetween treatments. Conversely, the pattern of shapeasymmetry was affected by the environmental perturba-tion since the angles between the first eigenvectorsextracted from the covariance matrix of shape asymmet-ric component of protein restricted and control groupswere not significantly different from the expected forrandom vectors. In addition, among-individual variancein cranial shape was significantly higher in the proteinrestricted than the control group at E18.5. Overall, theresults obtained from a controlled experiment do notsupport the view of fluctuating asymmetry of cranialstructures as a reliable index for inferring nutritionalstress in human populations.
Palabras clave: Protein Restriction , Fluctuating Asymmetry , Phenotypic Variation , Fetal Growth
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
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URI: http://hdl.handle.net/11336/32642
DOI: http://dx.doi.org/10.1002/ajpa.22545
URL: http://onlinelibrary.wiley.com/doi/10.1002/ajpa.22545/abstract
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Articulos(CCT - LA PLATA) [5122]
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Hallgrimsson, Benedikt; Lotto, Federico Pablo; Gonzalez, Paula Natalia; Canalization and Developmental Instability of the FetalSkull in a Mouse Model of Maternal Nutritional Stress; Wiley-liss, Div John Wiley & Sons Inc; American Journal Of Physical Anthropology; 154; 4; 8-2014; 544-553
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