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dc.contributor.author
Howard, Elizabeth J.
dc.contributor.author
Xiong, Xu
dc.contributor.author
Carlier, Yves
dc.contributor.author
Sosa-estani, Sergio Alejandro
dc.contributor.author
Buekens, Pierre
dc.date.available
2018-01-08T22:11:47Z
dc.date.issued
2013-08
dc.identifier.citation
Buekens, Pierre; Sosa-estani, Sergio Alejandro; Carlier, Yves; Xiong, Xu; Howard, Elizabeth J.; Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 1; 8-2013; 22-33
dc.identifier.issn
1470-0328
dc.identifier.uri
http://hdl.handle.net/11336/32613
dc.description.abstract
BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
Trypanosoma Cruzi
dc.subject
Chagas Disease
dc.subject
Congenital Infection
dc.subject
Meta-Analysis
dc.subject
Systematic Review
dc.subject.classification
Salud Ocupacional
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2018-01-08T19:47:01Z
dc.identifier.eissn
1471-0528
dc.journal.volume
121
dc.journal.number
1
dc.journal.pagination
22-33
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Howard, Elizabeth J.. University of Tulane; Estados Unidos
dc.description.fil
Fil: Xiong, Xu. University of Tulane; Estados Unidos
dc.description.fil
Fil: Carlier, Yves. Université Libre de Bruxelles; Bélgica
dc.description.fil
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
dc.journal.title
BJOG - An International Journal of Obstetrics and Gynaecology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12396/abstract
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/1471-0528.12396
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914719/


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