Artículo
Effect of GnRH analogs in postnatal domestic cats
Carranza Martin, Ana Cristina
; Faya, Marcela Inés
; López Merlo, Mariana Lucía
; Batista, Pablo Rodrigo
; Gobello, María Cristina
Fecha de publicación:
07/2014
Editorial:
Elsevier Science Inc
Revista:
Theriogenology
ISSN:
0093-691X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Resumen
The aim of this study was to reproductively assess the clinical and hormonal effects of a GnRH agonist (AG) and an antagonist (AN) administered during the postnatal period in domestic cats. Forty-eight male and female postnatal kittens were randomly assigned to deslorelin acetate 1.6 mg subcutaneous (AG; n¼16), acyline 33mg/100 g subcutaneous weekly for 3 months (AN; n¼16), or control (CO; n¼16) which remained untreated. The cats were followed up (behavioral observation, physical examination, fecal sexual steroid determinations, mating test, and pregnancy diagnosis) up to puberty. Puberty was delayed (weeks) in the AG animals (62.93.5; P<0.01) but not in the AN (15.51.7; P>0.05)when they were compared with CO kittens (13.40.4). Fifteen (15/16) of the AN and CO animals, and only 11 of 16 cats of the AG group were fertile (P>0.1). No differences were found in body weight (P >0.1) and measurements (P>0.1), libido (P>0.1) and in the appearance of side effects (P>0.1; except a pyometra in an AG female) among groups. In both AG- and AN-treated males (testosterone; P<0.01) and females (estradiol-17b;P<0.01) fecal hormone concentrations were lower than in CO group during thefirstfive postnatal weeks but not later. It is concluded that the neonatal administration of these AG and AN decreased fecal sexual steroids during thefirst postnatal weeks causing, the agonists but not the antagonist, a significant, reversible delay in puberty appearance.
Palabras clave:
Feline
,
Gnrh Agonist
,
Gnrh Antagonist
,
Neonate
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Batista, Pablo Rodrigo; López Merlo, Mariana Lucía; Faya, Marcela Inés; Carranza Martin, Ana Cristina; Gobello, María Cristina; Effect of GnRH analogs in postnatal domestic cats; Elsevier Science Inc; Theriogenology; 82; 1; 7-2014; 138-143
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