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dc.contributor.author
Larramendy, Marcelo Luis
dc.contributor.author
Nikoloff, Noelia
dc.contributor.author
Ruiz de Arcaute, Celeste
dc.contributor.author
Soloneski, Sonia Maria Elsa
dc.date.available
2018-01-08T14:31:40Z
dc.date.issued
2014-05
dc.identifier.citation
Ruiz de Arcaute, Celeste; Soloneski, Sonia Maria Elsa; Nikoloff, Noelia; Larramendy, Marcelo Luis; Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation; OMICS Publishing Group; Journal of Environmental and Analytical Toxicology; 4; 4; 5-2014; 1-10
dc.identifier.issn
2161-0525
dc.identifier.uri
http://hdl.handle.net/11336/32508
dc.description.abstract
Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still unsolved. Recent technological advances in molecular biology and analytical science have allowed the development of rapid, robust, and sensitive diagnostic tests (biomarkers) that can be used to monitor exposure to, and the effects of pollution. One of the major goals of our research laboratory is to evaluate comparatively the genotoxic and cytotoxic effects exerted by several pure agrochemicals and their technical formulations commonly used in Argentina on vertebrate cells in vitro and in vivo employing several end-points for geno and cytotoxicity. Among them are listed the herbicides dicamba and flurochloridone, the fungicide zineb, the insecticides pirimicarb and imidacloprid. Overall, the results clearly demonstrated that the damage induced by the commercial formulations is in general greater than that produced by the pure pesticides, suggesting the presence of deleterious components in the excipients with either a putative intrinsic toxic effect Larramendy et al. 4 or with the capacity of exacerbating 52 the toxicity of the pure agrochemicals, or both. Accordingly, the results highlight that: 1) A complete knowledge of the toxic effect/s of the active ingredient is not enough in biomonitoring studies; 2) Pesticide/s toxic effect/s should be evaluated assaying to the commercial formulation available in market; 3) The deleterious effect/s of the excipient/s present within the commercial formulation should not be either discarded nor underestimated, and 4) A single bioassay is not enough to characterize the toxicity of a agrochemical under study.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Agrochemicals
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Pesticides
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Commercial Formulations
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In Vitro
dc.subject
In Vivo
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Biomarkers
dc.subject.classification
Otras Ciencias Biológicas
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Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-26T14:29:29Z
dc.journal.volume
4
dc.journal.number
4
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Sunnyvale
dc.description.fil
Fil: Larramendy, Marcelo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina
dc.description.fil
Fil: Nikoloff, Noelia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina
dc.description.fil
Fil: Ruiz de Arcaute, Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina
dc.description.fil
Fil: Soloneski, Sonia Maria Elsa. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina
dc.journal.title
Journal of Environmental and Analytical Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2161-0525.1000225
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.omicsonline.org/open-access/genotoxicity-and-cytotoxicity-exerted-by-pesticides-in-different-biotic-matricesan-overview-of-more-than-a-decade-of-experimental-evaluation-2161-0525.1000225.php?aid=27549


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