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Artículo

Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor

Ghersi, Marisa SoledadIcon ; Gabach, LauraIcon ; Buteler, Florencia; Vilcaes, Aldo AlejandroIcon ; Schiöth, H. B.; Perez, Mariela FernandaIcon ; Rubiales, Susana ElizabethIcon
Fecha de publicación: 12/2014
Editorial: Springer
Revista: Psychopharmacology
ISSN: 0033-3158
e-ISSN: 1432-2072
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Inmunología

Resumen

Rationale: Ghrelin (Ghr) is a peptide that participates in the modulation of several biological processes. Ghr administration into the hippocampus improves learning and memory in different memory tests. However, the possible mechanisms underlying this effect on memory have not yet been clarified. Objective: The purpose of the present work is to add new insights about the mechanisms by which Ghr modulates long-term memory consolidation in the hippocampus. We examined Ghr effects upon processes related to increased synaptic efficacy as presynaptic glutamate release and changes in the expression of the NR2B-subunits containing n-methyl-d-aspartate receptors (NMDAR), which are critical for LTP induction. We also attempted to determine the temporal window in which Ghr administration induces memory facilitation and if the described effects depend on GHS-R1a stimulation. Results: The present research demonstrated that Ghr increased glutamate release from hippocampal synaptosomes; intra-hippocampal Ghr administration increased NR2B-subunits expression in CA1 and DG subareas and also reversed the deleterious effects of the NR2B-subunit-specific antagonist, Ro 25-6981, upon memory consolidation and LTP generation in the hippocampus. These effects are likely to be the consequence of GHS-R1a activation. Conclusion: According to the results above mentioned and previous findings, we can hypothesize some of the mechanisms by which Ghr modulates memory consolidation. At presynaptic level, Ghr stimulates glutamate release, probably by enhancing [Ca2+]i. At postsynaptic level, the glutamate released activates NMDAR while Ghr also mediates effects directly activating its specific receptors and increases NR2B-subunit expression.
Palabras clave: Ghrelin , Memory , Nr2b Subunit
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/32452
DOI: http://dx.doi.org/10.1007/s00213-014-3817-6
URL: https://link.springer.com/article/10.1007%2Fs00213-014-3817-6
Colecciones
Articulos(IFEC)
Articulos de INST. DE FARMACOLOGIA EXPERIMENTAL DE CORDOBA
Citación
Rubiales, Susana Elizabeth; Schiöth, H. B.; Ghersi, Marisa Soledad; Gabach, Laura; Buteler, Florencia; Vilcaes, Aldo Alejandro; et al.; Ghrelin increases memory consolidation through hippocampal mechanisms dependent on glutamate release and NR2B-subunits of the NMDA receptor; Springer; Psychopharmacology; 232; 10; 12-2014; 1843-1857
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