Artículo
Increasing Doxycycline Hyclate Photostability by Complexation with β-Cyclodextrin
Kogawa, Ana Carolina; Zoppi, Ariana
; Quevedo, Mario Alfredo
; Salgado, Hérida Regina Nunes; Longhi, Marcela Raquel
Fecha de publicación:
06/2014
Editorial:
Springer
Revista:
AAPS Pharmscitech
e-ISSN:
1530-9932
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Doxycycline hyclate (DOX) is a highly photosensitive drug, a feature that limits the stability of the corresponding dosage forms. The main objectives of this work were the preparation and characterization of an inclusion complex of DOX with β-cyclodextrin (βCD) and to investigate if this approach could improve the photostability of the drug. Guest-host interactions were investigated using nuclear magnetic resonance, which were afterwards combined with molecular modeling methods to study the complex formation and its three-dimensional structure was proposed. A freeze-drying method was applied to obtain the complex in the solid state, which was further confirmed by thermal and spectroscopic techniques. To evaluate the complexation effect on DOX integrity, the photostability of the inclusion complex was studied, with a significant decrease in the photodegradation of DOX being found in aqueous solution upon complexation. Finally, the photoprotection produced by the complexation was evaluated by means of an antimicrobial assay. Overall, the presented results suggest that the formulation of DOX complexed with βCD constitutes an interesting approach for the preparation of pharmaceutical dosage forms of DOX with enhanced stability properties.
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Articulos(UNITEFA)
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Articulos de UNIDAD DE INVESTIGACION Y DESARROLLO EN TECNOLOGIA FARMACEUTICA
Citación
Longhi, Marcela Raquel; Salgado, Hérida Regina Nunes; Kogawa, Ana Carolina; Quevedo, Mario Alfredo; Zoppi, Ariana; Increasing Doxycycline Hyclate Photostability by Complexation with β-Cyclodextrin
; Springer; AAPS Pharmscitech; 15; 5; 6-2014; 1209-1217
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