Artículo
Random inbreeding, isonymy, and population isolates in Argentina
Dipierri, Jose Edgardo; Rodriguez Larralde, Alvaro; Barrai, Italo; López Camelo, Jorge Santiago
; Gutierrez Redomero, Esperanza; Alonso Rodriguez, Concepcion; Ramallo, Virginia
; Bronberg, Ruben; Alfaro Gómez, Emma Laura
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Fecha de publicación:
02/2014
Editorial:
Springer Verlag Berlín
Revista:
Journal of Community Genetics
ISSN:
1868-310X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Population isolates are an important tool in identi-fying and mapping genes of Mendelian diseases and complextraits. The geographical identification of isolates represents apriority from a genetic and health care standpoint. The pur-pose of this study is to analyze the spatial distribution ofconsanguinity by random isonymy (FST)inArgentinaanditsrelationship with the isolates previously identified in thecountry.FSTwas estimated from the surname distribution of22.6 million electors registered for the year 2001 in the 24provinces, 5 geographical regions, and 510 departments of thecountry. Statistically significant spatial clustering ofFSTwasdetermined using the SaTScan V5.1 software.FSTexhibited amarked regional and departamental variation, showing thehighest values towards the North and West of Argentina.The clusters of high consanguinity by random isonymyfollowed the same distribution. Recognized Argentinean ge-netic isolates are mainly localized at the north of the country,in clusters of high inbreeding. Given the availability of listingsof surnames in high-capacity storage devices for differentcountries, estimatingFSTfrom them can provide informationon inbreeding for all levels of administrative subdivisions, tobe used as a demographic variable for the identification ofisolates within the country for public health purposes.
Palabras clave:
Surnames
,
Random Isonymy
,
Consanguinity
,
Clusters
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IMBICE)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Articulos de INST.MULTIDISCIPL.DE BIOLOGIA CELULAR (I)
Citación
Alfaro Gómez, Emma Laura; Bronberg, Ruben; Ramallo, Virginia; Alonso Rodriguez, Concepcion; Gutierrez Redomero, Esperanza; López Camelo, Jorge Santiago; et al.; Random inbreeding, isonymy, and population isolates in Argentina; Springer Verlag Berlín; Journal of Community Genetics; 5; 3; 2-2014; 241-248
Compartir
Altmétricas