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dc.contributor.author
Vallés, Patricia G.
dc.contributor.author
Gil Lorenzo, Andrea Fernanda
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dc.contributor.author
Bocanegra, María Victoria
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dc.contributor.author
Valles, Roberto
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dc.date.available
2018-01-03T20:32:08Z
dc.date.issued
2014-06
dc.identifier.citation
Valles, Roberto; Bocanegra, María Victoria; Gil Lorenzo, Andrea Fernanda; Vallés, Patricia G.; Acute kidney injury: what part do toll-like receptors play?; Dove Press; International Journal of Nephrology and Renovascular Disease; 2014; 7; 6-2014; 241-251
dc.identifier.issn
1178-7058
dc.identifier.uri
http://hdl.handle.net/11336/32214
dc.description.abstract
The innate immune system plays an important role as a first response to tissue injury. This first response is carried out via germline-encoded receptors. Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition receptors. TLRs are expressed on a variety of cell types, including epithelial cells, endothelia, dendritic cells, monocytes/macrophages, and B- and T-cells. TLRs initiate innate immune responses and concurrently shape the subsequent adaptive immune response. They are sensors of both pathogens, through the exogenous pathogen-associated molecular patterns (PAMPs), and tissue injury, through the endogenous danger-associated molecular patterns (DAMPs). TLR signaling is critical in defending against invading microorganisms; however, sustained receptor activation is also implicated in the pathogenesis of inflammatory diseases. Ischemic kidney injury involves early TLR-driven immunopathology, and the resolution of inflammation is needed for rapid regeneration of injured tubule cells. Notably, the activation of TLRs also has been implicated in epithelial repair. This review focuses on the role of TLRs and their endogenous ligands within the inflammatory response of acute kidney injury.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Dove Press
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.subject
Toll-Like Receptors
dc.subject
Pathogen-Associated Molecular Patterns
dc.subject
Danger-Associated Molecular Patterns
dc.subject
Ischemic Kidney Injury
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Acute kidney injury: what part do toll-like receptors play?
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-29T14:11:04Z
dc.journal.volume
2014
dc.journal.number
7
dc.journal.pagination
241-251
dc.journal.pais
Nueva Zelanda
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dc.journal.ciudad
Auckland
dc.description.fil
Fil: Vallés, Patricia G.. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Gil Lorenzo, Andrea Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Bocanegra, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Valles, Roberto. Universidad Nacional de Cuyo; Argentina
dc.journal.title
International Journal of Nephrology and Renovascular Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/ 10.2147/IJNRD.S37891
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069137/
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/acute-kidney-injury-what-part-do-toll-like-receptors-play-peer-reviewed-article-IJNRD
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