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Artículo

Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats

Sasso, Corina VerónicaIcon ; Santiano, Flavia ElianaIcon ; López Fontana, Constanza MatildeIcon ; Pistone Creydt, VirginiaIcon ; Ezquer, Eduardo MarceloIcon ; Hapon, María BelénIcon ; Jahn, Graciela AlmaIcon ; Caron, Ruben WalterIcon
Fecha de publicación: 07/2014
Editorial: Hindawi Publishing Corporation
Revista: BioMed Research International
ISSN: 2314-6133
e-ISSN: 2314-6141
Idioma: Inglés
Tipo de recurso: Artículo publicado

Resumen

Prolactin (PRL) is a key player in the development of mammary cancer. We studied the effects of parity or hyperprolactinemia on mammary carcinogenesis in OFA hr/hr treated with 7,12-dimethylbenzanthracene. They were divided into three groups: nulliparous (Null), primiparous (PL, after pregnancy and lactation), and hyperprolactinemic rats (I, implanted in the arcuate nucleus with 17β-estradiol). The tumor incidence was similar in the three groups. However, a higher percentage of regressing tumors was evident in the PL group. Serum PRL, mammary development, and mammary β-casein content were higher in I rats compared to Null. The expression of hormone receptors was similar in the different groups. However, mammary tissue from PL rats bearing tumors had increased expression of PRL and estrogen alpha receptors compared to rats free of tumors. Our results suggest that serum PRL levels do not have relevance on the incidence of tumors, probably because the low levels of PRL in OFA rats are not further decreased by PL like in other strains. However, supraphysiological levels of PRL affect carcinogenesis. PL induces regression of the tumors due to the differentiation produced on the mammary cells. Alterations in the expression of hormonal receptors may be involved in progression and regression of tumors.
Palabras clave: Pregnancy , Lactation , Breast Cancer , Involution
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution 2.5 Unported (CC BY 2.5)
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URI: http://hdl.handle.net/11336/32091
URL: http://www.hindawi.com/journals/bmri/2014/210424/
DOI: http://dx.doi.org/10.1155/2014/210424
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Articulos(IMBECU) [385]
Articulos de INST. DE MEDICINA Y BIO. EXP. DE CUYO
Citación
Sasso, Corina Verónica; Santiano, Flavia Eliana; López Fontana, Constanza Matilde; Pistone Creydt, Virginia; Ezquer, Eduardo Marcelo; et al.; Effects of Parity and Serum Prolactin Levels on the Incidence and Regression of DMBA-Induced Tumors in OFA hr/hr Rats; Hindawi Publishing Corporation; BioMed Research International; 2014; 7-2014; 1-11
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