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dc.contributor.author
Savastano, Luis E.
dc.contributor.author
Laurito, Sergio Roberto
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Fitt, Marcos R.
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Rasmussen, Jorge A.
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Gonzalez Polo, Virginia
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Patterson, Sean Ingram
dc.date.available
2018-01-02T20:42:38Z
dc.date.issued
2014-01
dc.identifier.citation
Patterson, Sean Ingram; Gonzalez Polo, Virginia; Rasmussen, Jorge A.; Fitt, Marcos R.; Laurito, Sergio Roberto; Savastano, Luis E.; et al.; Sciatic nerve injury: A simple and subtle model for investigating many aspects of nervous system damage and recovery; Elsevier; Journal of Neuroscience Methods; 227; 1-2014; 166-180
dc.identifier.issn
0165-0270
dc.identifier.uri
http://hdl.handle.net/11336/32044
dc.description.abstract
Sciatic nerve injury has been used for over a century to investigate the process of nerve damage, to assess the absolute and relative capacity of the central and peripheral nervous systems to recover after axotomy, and to understand the development of chronic pain in many pathologies. Here we provide a historical review of the contributions of this experimental model to our current understanding of fundamental questions in the neurosciences, and an assessment of its continuing capacity to address these and future problems. We describe the different degrees of nerve injury - neurapraxia, axonotmesis, neurotmesis - together with the consequences of selective damage to the different functional and anatomic components of this nerve. The varied techniques used to model different degrees of nerve injury and their relationship to the development of neuropathic pain states are considered. We also provide a detailed anatomical description of the sciatic nerve from the spinal cord to the peripheral branches in the leg. A standardized protocol for carrying out sciatic nerve axotomy is proposed, with guides to assist in the accurate and reliable dissection of the peripheral and central branches of the nerve. Functional, histological, and biochemical criteria for the validation of the injury are described. Thus, this paper provides a review of the principal features of sciatic nerve injury, presents detailed neuroanatomical descriptions of the rat´s inferior limb and spine, compares different modes of injury, offers material for training purposes, and summarizes the immediate and longterm consequences of damage to the sciatic nerve.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Axotomy
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Conditioning Lesion
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Dorsal Root Ganglion
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Sciatic Nerve Injury
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Neuropathic Pain
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Sensory Neuron
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Sciatic nerve injury: A simple and subtle model for investigating many aspects of nervous system damage and recovery
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-29T14:12:44Z
dc.journal.volume
227
dc.journal.pagination
166-180
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Savastano, Luis E.. Universidad Nacional de Cuyo; Argentina
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Fil: Laurito, Sergio Roberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Fitt, Marcos R.. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Rasmussen, Jorge A.. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Gonzalez Polo, Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.description.fil
Fil: Patterson, Sean Ingram. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Cienicas Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
dc.journal.title
Journal of Neuroscience Methods
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0165027014000314
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jneumeth.2014.01.020
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