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dc.contributor.author
Nadin, Silvina Beatriz
dc.contributor.author
Sottile Fleury, Mayra Lis
dc.contributor.author
Montt Guevara, Maria Magdalena
dc.contributor.author
Gauna, Gisel Valeria
dc.contributor.author
Daguerre, Pedro
dc.contributor.author
Leuzzi, Marcela
dc.contributor.author
Gago, Francisco E.
dc.contributor.author
Ibarra, Jorge
dc.contributor.author
Cuello Carrión, Fernando Darío
dc.contributor.author
Ciocca, Daniel Ramon
dc.contributor.author
Vargas Roig, Laura Maria
dc.date.available
2018-01-02T18:45:06Z
dc.date.issued
2013-12
dc.identifier.citation
Vargas Roig, Laura Maria; Ciocca, Daniel Ramon; Cuello Carrión, Fernando Darío; Ibarra, Jorge; Gago, Francisco E.; Leuzzi, Marcela; et al.; Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy; Springer; Cell Stress & Chaperones; 19; 4; 12-2013; 493-505
dc.identifier.issn
1355-8145
dc.identifier.uri
http://hdl.handle.net/11336/32014
dc.description.abstract
Neoadjuvant chemotherapy is used in patients with locally advanced breast cancer to reduce the tumor size before surgery. Unfortunately, resistance to chemotherapy may arise from a variety of mechanisms. The heat shock proteins (HSPs), which are highly expressed in mammary tumor cells, have been implicated in anticancer drug resistance. In spite of the widely described value of HSPs as molecular markers in cancer, their implications in breast tumors treated with anthracycline-based neoadjuvant chemotherapy has been poorly explored. In this study, we have evaluated by immunohistochemistry the expression of HSP27 (HSPB1) and HSP70 (HSPA) in serial biopsies from locally advanced breast cancer patients (n= 60) treated with doxorubicin (DOX) or epirubicin (EPI) based monochemotherapy. The serial biopsies were taken at days 1, 3, 7, 21, and compared with the pre-chemotherapy and the surgical biopsies. After surgery the patients received additional chemotherapy with Cyclophosphamide, Methotrexate and 5-Fluorouracil (CMF). High nuclear HSPB1 and HSPA expressions were found in invasive cells after DOX/EPI administration (P<0.001), but the drug did not affect the cytoplasmic expression of the HSPs. Infiltrating lymphocytes showed high nuclear HSPA (P<0.01) levels at post-chemotherapy. No correlations were found between HSPs expression and the clinical and pathological response to neoadjuvant therapy. However, in the post-chemotherapy biopsies, high nuclear (>31% of the cells) and cytoplasmic HSPA expressions (>11% of the tumor cells) were associated with better DFS (P=0.0348 and P=0.0118, respectively). We conclude that HSPA expression may be a useful prognostic marker in breast cancer patients treated with neoadjuvant DOX/EPI chemotherapy, indicating the need to change the administered drugs after surgery for overcoming drug resistance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Breast Cancer
dc.subject
Neoadjuvant Chemotherapy
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Anthracyclines
dc.subject
Heat Shock Proteins
dc.subject
Prognostic Factors
dc.subject.classification
Medicina Critica y de Emergencia
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-29T14:17:04Z
dc.identifier.eissn
1466-1268
dc.journal.volume
19
dc.journal.number
4
dc.journal.pagination
493-505
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Nadin, Silvina Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Sottile Fleury, Mayra Lis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Montt Guevara, Maria Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Gauna, Gisel Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Daguerre, Pedro. Hospital Luis Lagomaggiore; Argentina
dc.description.fil
Fil: Leuzzi, Marcela. Hospital Luis Lagomaggiore; Argentina
dc.description.fil
Fil: Gago, Francisco E.. Universidad Nacional de Cuyo; Argentina
dc.description.fil
Fil: Ibarra, Jorge. Hospital Luis Lagomaggiore; Argentina
dc.description.fil
Fil: Cuello Carrión, Fernando Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Vargas Roig, Laura Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.journal.title
Cell Stress & Chaperones
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12192-013-0475-2
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12192-013-0475-2


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