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Artículo

Involvement of the brain renin–angiotensin system (RAS) in the neuroadaptive responses induced by amphetamine in a two-injection protocol

Paz, Maria ConstanzaIcon ; Marchese, Natalia AndreaIcon ; Stroppa, Maria MercedesIcon ; Gerez de Burgos, Nelia Marta; Imboden, Hans; Baiardi, Gustavo CarlosIcon ; Cancela, Liliana MarinaIcon ; Bregonzio Diaz, ClaudiaIcon
Fecha de publicación: 10/2014
Editorial: Elsevier Science
Revista: Behavioural Brain Research
ISSN: 0166-4328
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Salud Ocupacional

Resumen

A single or repeated exposure to psychostimulants induces long-lasting neuroadaptative changes. Different neurotransmitter systems are involved in these responses including the neuropeptide angiotensin II. Our study tested the hypothesis that the neuroadaptative changes induced by amphetamine produce alterations in brain RAS components that are involved in the expression of the locomotor sensitization to the psychostimulant drug. Wistar male rats, pretreated with amphetamine were used 7 or 21 days later to study AT1 receptors by immunohistochemistry and western blot and also angiotensinogen mRNA and protein in caudate putamen and nucleus accumbens. A second group of animals was used to explore the possible role of Ang II AT1 receptors in the expression of behavioral sensitization. In these animals treated in the same way, bearing intra-cerebral cannula, the locomotor activity was tested 21 days later, after an amphetamine challenge injection and the animals received an AT1 blocker, losartan, or saline 5 min before the amphetamine challenge. An increase of AT1 receptor density induced by amphetamine was found in both studied areas and a decrease in angiotensinogen mRNA and protein only in CPu at 21 days after treatment; meanwhile, no changes were established in NAcc. Finally, the increased locomotor activity induced by amphetamine challenge was blunted by losartan administration in CPu. No differences were detected in the behavioral sensitization when the AT1 blocker was injected in NAcc. Our results support the hypothesis of a key role of brain RAS in the neuroadaptative changes induced by amphetamine.
Palabras clave: Angiotensin Ii , Behavioral Sensitization , Amphetamine , At1 Receptors , Angiotensinogen
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/31956
DOI: http://dx.doi.org/10.1016/j.bbr.2014.07.021
URL: http://www.sciencedirect.com/science/article/pii/S0166432814004689
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Paz, Maria Constanza; Marchese, Natalia Andrea; Stroppa, Maria Mercedes; Gerez de Burgos, Nelia Marta; Imboden, Hans; et al.; Involvement of the brain renin–angiotensin system (RAS) in the neuroadaptive responses induced by amphetamine in a two-injection protocol; Elsevier Science; Behavioural Brain Research; 272; 10-2014; 314-323
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