Artículo
Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection
Arocena, Alfredo Raul
; Onofrio, Luisina Inés
; Pellegrini, Andrea Vanina
; Carrera Silva, Eugenio Antonio
; Paroli, Augusto Fabián
; Cano, Roxana Carolina; Aoki, Maria del Pilar
; Gea, Susana
Fecha de publicación:
02/2014
Editorial:
Wiley VCH Verlag
Revista:
European Journal of Immunology
ISSN:
0014-2980
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Myeloid-derived suppressor cells (MDSCs) are key players in the immune suppressivenetwork. During acute infection with the causative agent of Chagas disease,Trypanosomacruzi, BALB/c mice show less inflammation and better survival than C57BL/6 (B6) mice.In this comparative study, we found a higher number of MDSCs in the spleens and liversof infected BALB/c mice compared with infected B6 mice. An analysis of the two majorMDSCs subsets revealed a greater number of granulocytic cells in the spleens and liversof BALB/c mice when compared with that in B6 mice. Moreover, splenic MDSCs purifiedfrom infected BALB/c mice inhibited ConA-induced splenocyte proliferation. Mechanisticstudies demonstrated that ROS and nitric oxide were involved in the suppressive activityof MDSCs, with a higher number of infected CD8+T cells suffering surface-nitrationcompared to uninfected controls. An upregulation of NADPH oxidase p47 phox subunitand p-STAT3 occurred in MDSCs and infected IL-6 KO mice showed less recruitment ofMDSCs and impaired survival. Remarkably, in vivo depletion of MDSCs led to increasedproduction of IL-6, IFN-γ, and a Th17 response with very high parasitemia and mortality.These findings demonstrate a new facet of MDSCs as crucial regulators of inflammationduringT. cruziinfection.
Palabras clave:
Inflammation
,
Nitric Oxide
,
Mdscs
,
Trypanosoma Cruzi
,
Ros
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Articulos(CIBICI)
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Articulos de CENTRO DE INV.EN BIOQUI.CLINICA E INMUNOLOGIA
Citación
Arocena, Alfredo Raul; Onofrio, Luisina Inés; Pellegrini, Andrea Vanina; Carrera Silva, Eugenio Antonio; Paroli, Augusto Fabián; et al.; Myeloid-derived suppressor cells are key players in the resolution of inflammation during a model of acute infection; Wiley VCH Verlag; European Journal of Immunology; 44; 2-2014; 184-194
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