Artículo

Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling

Singh, Sandeep; Thakur, Naveen; Oliveira, Ana; Petruk, Ariel AlcidesIcon ; Hade, Mangesh Dattu; Sethi, Deepti; Bidon Chanal, Axel; Marti, Marcelo AdrianIcon ; Datta, H.; Parkesh, R.; Estrin, Dario ArielIcon ; Luque, F. Javier; Dikshit, Kanak L.
Fecha de publicación: 06/2014
Editorial: American Society for Biochemistry and Molecular Biology
Revista: Journal of Biological Chemistry (online)
ISSN: 0021-9258
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

Background: The HbN of Mycobacterium tuberculosis carries a potent nitric-oxide dioxygenase activity despite lacking a reductase domain. Results: The NADH-ferredoxin reductase system acts as an efficient partner for the reduction of HbN. Conclusion: The interactions of HbN with the reductase are modulated by its CD loop and the Pre-A region. Significance: The present study provides new insights into the mechanism of electron transfer during nitric oxide detoxification by HbN.
Palabras clave: Truncated Hemoglobin , Tuberculosis , Electron Transfer
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/31877
DOI: http://dx.doi.org/10.1074/jbc.M114.578187
URL: http://www.jbc.org/content/289/31/21573
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Articulos(INQUIMAE)
Articulos de INST.D/QUIM FIS D/L MATERIALES MEDIOAMB Y ENERGIA
Citación
Dikshit, Kanak L.; Luque, F. Javier; Estrin, Dario Ariel; Parkesh, R.; Datta, H.; Marti, Marcelo Adrian; et al.; Mechanistic Insight into the Enzymatic Reduction of Truncated Hemoglobin N of Mycobacterium tuberculosis: role of the CD loop and pre-A Motif in electron cycling ; American Society for Biochemistry and Molecular Biology; Journal of Biological Chemistry (online); 289; 6-2014; 21573-21583
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