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dc.contributor.author
Morales Arias, Jaime
dc.contributor.author
Meyers, Paul A.
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Bolontrade, Marcela Fabiana
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Rodriguez, Nidra
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Zhou, Zhichao
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Reddy, Krishna
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Chou, Alexander J.
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Koshkina, Nadezhda V.
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Kleinerman, Eugenie S.
dc.date.available
2017-12-28T19:15:56Z
dc.date.issued
2007-10
dc.identifier.citation
Kleinerman, Eugenie S.; Koshkina, Nadezhda V.; Chou, Alexander J.; Reddy, Krishna; Zhou, Zhichao; Rodriguez, Nidra; et al.; Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: potential consequences of granulocyte-colony-stimulating factor administration; John Wiley & Sons Inc; Cancer; 110; 7; 10-2007; 1568-1577
dc.identifier.issn
0008-543X
dc.identifier.uri
http://hdl.handle.net/11336/31862
dc.description.abstract
BACKGROUND: Ewing sarcoma (ES) is a highly vascular malignancy. It has been demonstrated that both angiogenesis and vasculogenesis contribute to the growth of ES tumors. Granulocyte-colony-stimulating factor (G-CSF), a cytokine known to stimulate bone marrow (BM) stem cell production and angiogenesis, is routinely administered to ES patients after chemotherapy. Whether ES cells and patient tumor samples express G-CSF and its receptor (G-CSFR) and whether treatment with this factor enhances tumor growth was examined. METHODS: Human ES cell lines were analyzed for expression of G-CSF and G-CSFR in vitro and in vivo. Sixty-eight paraffin-embedded and 15 frozen tumor specimens from patients with ES were also evaluated for the presence of G-CSF and G-CSFR. The in vivo effect of G-CSF on angiogenesis and BM cell migration was determined. Using a TC/7-1 human ES mouse model, the effect of G-CSF administration on ES tumors was investigated. RESULTS: G-CSF and G-CSFR protein and RNA expression was identified in all ES cell lines and patient samples analyzed. In addition, G-CSF was found to stimulate angiogenesis and BM cell migration in vivo. Tumor growth was found to be significantly increased in mice treated with G-CSF. The average tumor volume for the group treated with G-CSF was 1218 mm(3) compared with 577 mm(3) for the control group (P = .006). CONCLUSIONS: The findings that ES cells and patient tumors expressed both G-CSF and its receptor in vitro and in vivo and that the administration of G-CSF promoted tumor growth in vivo suggest that the potential consequences of G-CSF administration should be investigated further
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
John Wiley & Sons Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ewing´S Sarcoma
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G-Csf
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Progenitor Cell
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Angiogenesis
dc.title
Expression of granulocyte-colony-stimulating factor and its receptor in human Ewing sarcoma cells and patient tumor specimens: potential consequences of granulocyte-colony-stimulating factor administration
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-12T20:02:07Z
dc.identifier.eissn
1097-0142
dc.journal.volume
110
dc.journal.number
7
dc.journal.pagination
1568-1577
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
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Fil: Morales Arias, Jaime. University of Texas; Estados Unidos
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Fil: Meyers, Paul A.. Memorial Sloan Ket tering Cancer Center; Estados Unidos
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Fil: Bolontrade, Marcela Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. University of Texas; Estados Unidos
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Fil: Rodriguez, Nidra. University of Texas; Estados Unidos
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Fil: Zhou, Zhichao. University of Texas; Estados Unidos
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Fil: Reddy, Krishna. University of Texas; Estados Unidos
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Fil: Chou, Alexander J.. Memorial Sloan Ket tering Cancer Center; Estados Unidos
dc.description.fil
Fil: Koshkina, Nadezhda V.. University of Texas; Estados Unidos
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Fil: Kleinerman, Eugenie S.. University of Texas; Estados Unidos
dc.journal.title
Cancer
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cncr.22964/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/cncr.22964
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