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dc.contributor.author
Novotny Núñez, Ivanna
dc.contributor.author
Perdigón, Gabriela del Valle
dc.contributor.author
de Moreno, Maria Alejandra
dc.contributor.author
Maldonado Galdeano, María Carolina
dc.date.available
2015-12-22T20:34:08Z
dc.date.issued
2015-08
dc.identifier.citation
Novotny Núñez, Ivanna; Perdigón, Gabriela del Valle; de Moreno, Maria Alejandra; Maldonado Galdeano, María Carolina; Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet induced obese mouse model; Elsevier Science Inc; Nutrition; 31; 7-8; 8-2015; 1000-1007
dc.identifier.issn
0899-9007
dc.identifier.uri
http://hdl.handle.net/11336/3178
dc.description.abstract
Obesity is a chronic disease associated with an inflammatory process in which cytokines play an important role. Probiotic microorganisms have been associated with modulation of the host immune system. The aim of this study was to evaluate the influence of the probiotic bacterium Lactobacillus casei CRL 431 on the cytokine response in a model of mice under high-fat diet (HFD) conditions. Methods: BALB/c mice received a conventional balanced diet or an HFD. The test groups received milk, milk fermented by L. casei (FM), or L. casei as suspension in the drinking water. Proinflammatory and regulatory cytokine producer cells were evaluated in the small intestine and liver; the cytokine levels in the intestinal fluids were also evaluated. The percentages of immune cells as macrophages (F4/80), NKT, CD4þ, CD8þ populations were determined in the liver. Adipocytes were also isolated and cultured to evaluate cytokines and the chemokine monocyte chemoattractant protein (MCP)-1 produced by them. Results: The administration of probiotic L. casei CRL 431 exerted an anti-inflammatory response in mice fed an HFD, evidenced mainly by decreasing proinflammatory cytokines, such as interleukin (IL)-6, IL-17, and tumor necrosis factor-a. Probiotic administration also was associated with fewer immune-infiltrating cells in the liver of mice that received the HFD and decreased secretion of MCP-1 by the adipocytes. This last observation could be associated with less macrophage accumulation in the adipose tissues, which is characteristic in the obese host and contributes to maintaining the inflammatory response in this organ. The results obtained show an anti-inflammatory effect of L. casei CRL 431 when it is administered as a supplement of the HFD in a mouse model.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Cytokines
dc.subject
Probiotic
dc.subject
Diet Induced Obesity
dc.subject
Adypocytes
dc.subject
Small Intestine
dc.subject
Liver
dc.subject.classification
Nutrición, Dietética
dc.subject.classification
Ciencias de la Salud
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Lactobacillus casei CRL 431 administration decreases inflammatory cytokines in a diet induced obese mouse model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.identifier.eissn
1537-4513
dc.journal.volume
31
dc.journal.number
7-8
dc.journal.pagination
1000-1007
dc.journal.pais
Usa
dc.journal.ciudad
Tarrytown, NY
dc.description.fil
Fil: Novotny Núñez, Ivanna. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.description.fil
Fil: Perdigón, Gabriela del Valle. Universidad Nacional de Tucum án. Facultad de Bioqu ímica, Qu ímica y Farmacia. Instituto de Microbiolog ía. C átedra de Inmunolog ía; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.description.fil
Fil: de Moreno, Maria Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina
dc.description.fil
Fil: Maldonado Galdeano, María Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia para Lactobacilos (i); Argentina. Universidad Nacional de Tucum án. Facultad de Bioqu ímica, Qu ímica y Farmacia. Instituto de Microbiolog ía. C átedra de Inmunolog ía; Argentina
dc.journal.title
Nutrition
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.nut.2015.02.006
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/journal/08999007


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