Artículo

Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases

Trivillin, Verónica AndreaIcon ; Garabalino, Marcela Alejandra; Colombo, Lucas LuisIcon ; González, Sara JosefinaIcon ; Farías, Rubén OscarIcon ; Monti Hughes, AndreaIcon ; Pozzi, Emiliano César Cayetano; Bortolussi, Silva; Altieri, S.; Itoiz, María ElinaIcon ; Aromando, Romina Flavia; Nigg, D. W.; Schwint, Amanda ElenaIcon
Fecha de publicación: 12/2013
Editorial: Elsevier
Revista: Applied Radiation and Isotopes
ISSN: 0969-8043
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

BNCT was proposed for the treatment of diffuse, non-resectable tumors in the lung. We performed boron biodistribution studies with 5 administration protocols employing the boron carriers BPA and/or GB-10 in an experimental model of disseminated lung metastases in rats. All 5 protocols were non-toxic and showed preferential tumor boron uptake versus lung. Absolute tumor boron concentration values were therapeutically useful (25–76 ppm) for 3 protocols. Dosimetric calculations indicate that BNCT at RA-3 would be potentially therapeutic without exceeding radiotolerance in the lung.
Palabras clave: Boron Biodistribution Studies , Bpa , Gb-10 , Bnct , Boron Neutron Capture Therapy , Lung Metastases
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Atribución-NoComercial-SinDerivadas 2.5 Argentina (CC BY-NC-ND 2.5 AR)
Identificadores
URI: http://hdl.handle.net/11336/31778
URL: https://www.sciencedirect.com/science/article/pii/S0969804313005642
DOI: http://dx.doi.org/10.1016/j.apradiso.2013.11.115
Colecciones
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Citación
Trivillin, Verónica Andrea; Garabalino, Marcela Alejandra; Colombo, Lucas Luis; González, Sara Josefina; Farías, Rubén Oscar; et al.; Biodistribution of the boron carriers boronophenylalanine (BPA) and/or decahydrodecaborate (GB-10) for Boron Neutron Capture Therapy (BNCT) in an experimental model of lung metastases; Elsevier; Applied Radiation and Isotopes; 88; 12-2013; 94-98
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