Artículo
Maternal isolation during the first two postnatal weeks affects novelty-induced responses and sensitivity to ethanol-induced locomotor activity during infancy
Fernandez, Macarena Soledad
; Fabio, Maria Carolina
; Nizhnikov, Michael; Spear, Norman E.; Abate, Paula
; Pautassi, Ricardo Marcos
Fecha de publicación:
07/2014
Editorial:
John Wiley & Sons Inc
Revista:
Developmental Psychobiology
ISSN:
0012-1630
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Animals exposed to chronic maternal separation (MS) exhibit enhanced ethanol self-administration and greater hormonal and behavioral responsiveness to stress in adulthood. Whether the effects of MS are immediately evident in infancy or whether they appear only later on development is still an unanswered question This study tested sensitivity to ethanol's behavioral stimulating effects in infant rats that experienced MS from postnatal Day 1–14. MS infants exhibited significantly greater reactivity to the motor stimulating effects of 1.25 g/kg ethanol than control animals, yet greater motor suppression after 2.5 g/kg ethanol. Baseline level of response to novelty was altered in MS infants, in a nor-binaltorphimine insensitive manner, that is, despite modified activity of the kappa-opioid system. These results indicate that the consequences of chronic maternal isolation emerge early in ontogeny, affecting ethanol sensitivity in infancy.
Palabras clave:
Maternal Isolation
,
Rat
,
Ethanol
,
Preweanling
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Articulos(INIMEC - CONICET)
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Articulos de INSTITUTO DE INV. MEDICAS MERCEDES Y MARTIN FERREYRA
Citación
Fernandez, Macarena Soledad; Fabio, Maria Carolina; Nizhnikov, Michael; Spear, Norman E.; Abate, Paula; et al.; Maternal isolation during the first two postnatal weeks affects novelty-induced responses and sensitivity to ethanol-induced locomotor activity during infancy; John Wiley & Sons Inc; Developmental Psychobiology; 56; 5; 7-2014; 1070-1082
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