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dc.contributor.author
Martín, Mauricio Gerardo
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dc.contributor.author
Pfrieger, Frank
dc.contributor.author
Dotti, Carlos G.
dc.date.available
2017-12-27T13:44:01Z
dc.date.issued
2014-09
dc.identifier.citation
Martín, Mauricio Gerardo; Pfrieger, Frank; Dotti, Carlos G.; Cholesterol in brain disease: sometimesdeterminant and frequently implicated; Nature Publishing Group; Embo Reports; 15; 10; 9-2014; 1036-1052
dc.identifier.issn
1469-221X
dc.identifier.uri
http://hdl.handle.net/11336/31626
dc.description.abstract
Cholesterol is essential for neuronal physiology, both during development and in the adult life: as a major component of cell membranes and precursor of steroid hormones, it contributes to the regulation of ion permeability, cell shape, cell–cell interaction, and transmembrane signaling. Consistently, hereditary diseases with mutations in cholesterol‐related genes result in impaired brain function during early life. In addition, defects in brain cholesterol metabolism may contribute to neurological syndromes, such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD), and even to the cognitive deficits typical of the old age. In these cases, brain cholesterol defects may be secondary to disease‐causing elements and contribute to the functional deficits by altering synaptic functions. In the first part of this review, we will describe hereditary and non‐hereditary causes of cholesterol dyshomeostasis and the relationship to brain diseases. In the second part, we will focus on the mechanisms by which perturbation of cholesterol metabolism can affect synaptic function.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Nature Publishing Group
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Brain Disease
dc.subject
Cholesterol Metabolism
dc.subject
Cognition
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Cholesterol in brain disease: sometimesdeterminant and frequently implicated
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-26T20:37:09Z
dc.journal.volume
15
dc.journal.number
10
dc.journal.pagination
1036-1052
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Martín, Mauricio Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
dc.description.fil
Fil: Pfrieger, Frank. Université de Strasbourg; Francia
dc.description.fil
Fil: Dotti, Carlos G.. Universidad Autónoma de Madrid; España
dc.journal.title
Embo Reports
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.15252/embr.201439225
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://embor.embopress.org/content/15/10/1036
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