Artículo
The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems
Antunica Noguerol, María de Las Nieves
; Aprile García, Fernando
; Budziñski, Maia Ludmila
; Proto Cassina, Luciano Matias; Liberman, Ana Clara
; Arzt, Eduardo Simon
Fecha de publicación:
07/2014
Editorial:
IOS Press
Revista:
Advances in Neuroimmune Biology
ISSN:
1878-948X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post-translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits.
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Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Proto Cassina, Luciano Matias; Aprile García, Fernando; Antunica Noguerol, María de Las Nieves; Arzt, Eduardo Simon; Liberman, Ana Clara; Budziñski, Maia Ludmila; et al.; The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems; IOS Press; Advances in Neuroimmune Biology; 5; 1; 7-2014; 19-32
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