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Artículo

The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems

Antunica Noguerol, María de Las NievesIcon ; Aprile García, FernandoIcon ; Budziñski, Maia LudmilaIcon ; Proto Cassina, Luciano Matias; Liberman, Ana ClaraIcon ; Arzt, Eduardo SimonIcon
Fecha de publicación: 07/2014
Editorial: IOS Press
Revista: Advances in Neuroimmune Biology
ISSN: 1878-948X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

Glucocorticoids (GCs), the most downstream effectors of the hypothalamic-pituitary-adrenal (HPA) axis, are key mediators in the interaction between immune and neuroendocrine systems. They exert their biological actions mainly through binding to their intracellular receptor, the glucocorticoid receptor (GR), which in turn influences gene expression by interacting with transcription factors and/or coregulators. GR abnormal function has been extensively associated to stress-related disorders, inflammatory and autoimmune diseases. Therefore, modulating GR activity is critical to overcome pathological conditions. The final outcome of GCs actions in the immune and neuroendocrine systems is regulated at multiple levels, including post-translational modifications (PTMs) of GR as well as of protein complexes involved in GR signaling. Understanding the influence of PTMs on the molecular mechanisms involved in GR signaling is thus of utmost importance in the search for therapeutic strategies aimed at modulating GR responses under pathophysiological circumstances, and to understand the neuroimmune circuits.
Palabras clave: Glucocorticoid Receptor , Post-Translational Modifications , Neuroimmunology , Transcription Regulation
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/31597
URL: https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib140083
DOI: http://dx.doi.org/10.3233/NIB-140083
Colecciones
Articulos(IBIOBA - MPSP)
Articulos de INST. D/INV.EN BIOMED.DE BS AS-CONICET-INST. PARTNER SOCIEDAD MAX PLANCK
Citación
Proto Cassina, Luciano Matias; Aprile García, Fernando; Antunica Noguerol, María de Las Nieves; Arzt, Eduardo Simon; Liberman, Ana Clara; Budziñski, Maia Ludmila; et al.; The Interplay between the Glucocorticoid Receptor Activity and post-Translational Modifications in the Immune and Neuroendocrine Systems; IOS Press; Advances in Neuroimmune Biology; 5; 1; 7-2014; 19-32
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