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dc.contributor.author
D'alessandro, Maria Eugenia Guadalupe  
dc.contributor.author
Oliva, Maria Eugenia  
dc.contributor.author
Fortino, María Alejandra  
dc.contributor.author
Chicco, Adriana Graciela  
dc.date.available
2017-12-26T19:53:46Z  
dc.date.issued
2013-12  
dc.identifier.citation
D'alessandro, Maria Eugenia Guadalupe; Oliva, Maria Eugenia; Fortino, María Alejandra; Chicco, Adriana Graciela; Maternal sucrose-rich diet and fetal programming: changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis in adult offspring; Royal Society of Chemistry; Food & Function; 5; 3; 12-2013; 446-453  
dc.identifier.issn
2042-6496  
dc.identifier.uri
http://hdl.handle.net/11336/31579  
dc.description.abstract
Nutritional insults during pregnancy and lactation (P+L) are often associated with offspring health risks. We investigated the effect of maternal exposure to a sucrose-rich diet (SRD) during P+L on glucose and lipid metabolism of adult offspring regardless of post-weaning diet. Dams were fed an SRD or a control diet (CD) during P+L. After weaning, male offspring from SRD and CD dams were divided in two groups and fed a CD or SRD until 150-days old forming CD-CD, CD-SRD, SRD-SRD and SRD-CD groups. Offspring where SRD was fed at any period of life showed: 1) Increased adipose tissue weight without changes in final body weight; 2) Dyslipidemia as result of increased very low density lipoprotein triglyceride secretion rate and decreased triglyceride clearance; 3) Hepatic steatosis associated with increased activity of key enzymes involved in liver de novo lipogenesis and significant decrease of the activity of mitochondrial fatty acid oxidation enzyme. These results were more pronounced in CDSRD and SRD-SRD groups. 4) Hyperglycemia without changes in insulin levels, plus a deterioration of intravenous glucose tolerance and intraperitoneal insulin tolerance test. We hypothesized that SRD during P+L could be associated with a programming effect on glucose homeostasis and hepatic lipid metabolism that predispose offspring to develop later-life insulin resistance and metabolic disorders, regardless of post-natal diet. Journal of citation of citation Reports Thomson reuters: IF: 2.694. Paper aceptado (10-12-13) y en prensa.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Royal Society of Chemistry  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Sucrose-Rich Diet  
dc.subject
Fetal Programming  
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Metabolic Disorder  
dc.subject
Lipogenic Enzymes  
dc.subject.classification
Fisiología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Maternal sucrose-rich diet and fetal programming: changes in hepatic lipogenic and oxidative enzymes and glucose homeostasis in adult offspring  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-12-21T14:10:17Z  
dc.journal.volume
5  
dc.journal.number
3  
dc.journal.pagination
446-453  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: D'alessandro, Maria Eugenia Guadalupe. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.description.fil
Fil: Oliva, Maria Eugenia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.description.fil
Fil: Fortino, María Alejandra. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.description.fil
Fil: Chicco, Adriana Graciela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina  
dc.journal.title
Food & Function  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/C3FO60436E  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2014/FO/c3fo60436e