Artículo
Fruits of the glossy privet (Ligustrum lucidum—Oleaceae) as biocatalysts for producing chiral aromatic alcohols
Aimar, Mario Leandro; Bordon, Daniela Laura; Formica, Stella Maris; Cantero, Juan Jose; Vazquez, Ana M.; Velasco, Manuel Isaac
; Rossi, Laura Isabel
Fecha de publicación:
12/2014
Editorial:
Taylor & Francis Ltd
Revista:
Biocatalysis and Biotransformation
ISSN:
1024-2422
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The screening of four invasive plant species for use as biocatalysts in the stereoselective reduction of ketones is reported. Our studies revealed that fruits of Ligustrum lucidum can be used for the bioreduction of acetophenone to (S)-1-phenylethanol (94% conversion, > 99 enantiomeric excess [ee]%). Using this methodology, 13 substituted (S)-phenylethanols were synthesized with good ee values (> 99.9 to 78%) using a technique which is more environmentally friendly than classical reduction of prochiral ketones. The results reveal the fruits of L. lucidum to be promising biocatalysts for the production of key intermediates.
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Articulos(INFIQC)
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Articulos de INST.DE INVESTIGACIONES EN FISICO- QUIMICA DE CORDOBA
Citación
Rossi, Laura Isabel; Velasco, Manuel Isaac; Vazquez, Ana M.; Formica, Stella Maris; Bordon, Daniela Laura; Aimar, Mario Leandro; et al.; Fruits of the glossy privet (Ligustrum lucidum—Oleaceae) as biocatalysts for producing chiral aromatic alcohols; Taylor & Francis Ltd; Biocatalysis and Biotransformation; 32; 5-6; 12-2014; 348-357
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