Artículo
Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment
Chamosa, Luciana Soledad
; Alvarez, Verónica Elizabeth
; Nardelli, Maximiliano
; Quiroga, María Paula
; Cassini, Marcelo Hernan
; Centron, Daniela
Fecha de publicación:
31/03/2017
Editorial:
Nature Publishing Group
Revista:
Scientific Reports
e-ISSN:
2045-2322
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Historically, the environment has been viewed as a passive deposit of antimicrobial resistance mechanisms, where bacteria show biological cost for maintenance of these genes. Thus, in the absence of antimicrobial pressure, it is expected that they disappear from environmental bacterial communities. To test this scenario, we studied native IntI1 functionality of 11 class 1 integron-positive environmental strains of distant genera collected in cold and subtropical forests of Argentina. We found natural competence and successful site-specific insertion with no significant fitness cost of both aadB and bla <sub>VIM-2</sub> antimicrobial resistance gene cassettes, in a model system without antibiotic pressure. A bidirectional flow of antimicrobial resistance gene cassettes between natural and nosocomial habitats is proposed, which implies an active role of the open environment as a reservoir, recipient and source of antimicrobial resistance mechanisms, outlining an environmental threat where novel concepts of rational use of antibiotics are extremely urgent and mandatory.
Palabras clave:
Class 1 Integrons
,
Bla Vim-2
,
Antimicrobial Resistance
,
Resistome
Archivos asociados
Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos(IMPAM)
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Articulos de INSTITUTO DE INVESTIGACIONES EN MICROBIOLOGIA Y PARASITOLOGIA MEDICA
Citación
Chamosa, Luciana Soledad; Alvarez, Verónica Elizabeth; Nardelli, Maximiliano; Quiroga, María Paula; Cassini, Marcelo Hernan; et al.; Lateral Antimicrobial Resistance Genetic Transfer is active in the open environment; Nature Publishing Group; Scientific Reports; 7; 1; 31-3-2017; 513
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