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dc.contributor.author
Gonzalez Deniselle, Maria Claudia
dc.contributor.author
Garay, Laura Ines
dc.contributor.author
Gonzalez, Susana Laura
dc.contributor.author
Guennoun, Rachida
dc.contributor.author
Schumacher, Michael
dc.contributor.author
de Nicola, Alejandro Federico
dc.date.available
2017-12-23T19:44:58Z
dc.date.issued
2005-10
dc.identifier.citation
de Nicola, Alejandro Federico; Schumacher, Michael; Guennoun, Rachida; Gonzalez, Susana Laura; Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; et al.; Progesterone restores retrograde labelling of cervical motoneurons in Wobbler mouse motoneuron disease; Academic Press Inc Elsevier Science; Experimental Neurology; 195; 2; 10-2005; 518-523
dc.identifier.issn
0014-4886
dc.identifier.uri
http://hdl.handle.net/11336/31467
dc.description.abstract
The Wobbler mouse, a mutant characterized by motoneuron degeneration in the cervical spinal cord, has been used to test the efficacy of novel treatments for human motoneuron diseases (HMD). Previous reports have shown that slow axonal transport is impaired in Wobblers and other models of HMD. Since progesterone (PROG) corrects some morphological, molecular, and functional abnormalities of Wobbler mice, we studied if steroid exposure for 8 weeks restored retrograde axonal transport by measuring motoneuron labeling after injection of fluorogold into the limb muscles. The dye was injected into forelimb biceps bracchii and flexor or into the rearlimb gastrocnemius muscles; 6 days later, the number of fluorescent motoneurons and the total number of cresyl violet stained motoneurons were counted in the cervical (C5-T1) or lumbar (L3-L5) spinal cord regions. A pronounced reduction (- 42.2%) of the percent of fluorescent motoneurons in Wobbler mice cervical cord was noted, which was significantly corrected after PROG treatment. In contrast, labeling of lumbar motoneurons was not reduced in Wobbler mice and was not affected by PROG treatment. In no case PROG showed an effect in control mice. Concomitantly, PROG slightly but significantly increased biceps weight of Wobbler mice. Behaviorally, PROG-treated Wobblers performed better on a motor test (hanging time from a horizontal rope) compared to untreated counterparts. We postulate a dual role for PROG in the Wobbler mouse, in part by prevention of motoneuron degeneration and also by enhancement of axonal transport. The latter mechanism could improve the traffic of neurotrophic factors from the forelimb muscles into the ailing motoneurons, improving neuromuscular function in this murine model of HMD.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Academic Press Inc Elsevier Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Wobbler
dc.subject
Amyotrophic Lateral Sclerosis
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Neurodegeneration
dc.subject
Progesterone
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Progesterone restores retrograde labelling of cervical motoneurons in Wobbler mouse motoneuron disease
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-19T18:38:04Z
dc.identifier.eissn
1090-2430
dc.journal.volume
195
dc.journal.number
2
dc.journal.pagination
518-523
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Gonzalez Deniselle, Maria Claudia. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Garay, Laura Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Gonzalez, Susana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina
dc.description.fil
Fil: Guennoun, Rachida. Inserm; Francia
dc.description.fil
Fil: Schumacher, Michael. Inserm; Francia
dc.description.fil
Fil: de Nicola, Alejandro Federico. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Instituto Universidad de la Fundación ; Argentina
dc.journal.title
Experimental Neurology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0014488605002232?via%3Dihub
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.expneurol.2005.06.015
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/16095593


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