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dc.contributor.author
Vera Candioti, Josefina
dc.contributor.author
Soloneski, Sonia Maria Elsa
dc.contributor.author
Larramendy, Marcelo Luis
dc.date.available
2017-12-22T21:16:47Z
dc.date.issued
2013-05
dc.identifier.citation
Larramendy, Marcelo Luis; Soloneski, Sonia Maria Elsa; Vera Candioti, Josefina; Chlorpyrifos-based insecticides induced genotoxic and cytotoxic effects in the ten spotted live-bearer fish, Cnesterodon decemmaculatus (Jenyns, 1842); Wiley; Environmental Toxicology; 29; 12; 5-2013; 1390-1398
dc.identifier.issn
1520-4081
dc.identifier.uri
http://hdl.handle.net/11336/31455
dc.description.abstract
Mortality, genotoxicity, and cytotoxicity of the 48% chlorpyrifos (CPF)-based formulations Lorsban* 48E® and CPF Zamba® were evaluated on Cnesterodon decemmaculatus (Jenyns, 1842) (Pisces, Poeciliidae) under laboratory conditions. Induction of micronucleus (MN) and alterations in the erythrocyte/erythroblast frequencies were employed as end points for genotoxicity and cytotoxicity, respectively. For Lorsban* 48E®, mean values of 0.13 and 0.03 mg/L were determined for LC50 at 24 and 96 h, respectively, and these concentrations reached mean values of 0.40 and 0.21 mg/L for CPF Zamba®. Mortality values increased as a positive linear function of the CPF Zamba® concentrations, but not for Lorsban* 48E® concentrations. There was no significant relationship between mortality and exposure time within the 0–96 h period for both formulations. LC50 values indicated that the fish were seven fold more sensitive to Lorsban* 48E® than to CPF Zamba®. Lorsban* 48E® within the concentration range of 0.008–0.025 mg/L increased MN frequency at both 48 and 96 h of treatment. Similar results were also observed when fish were exposed to 0.052–0.155 mg/L of CPF Zamba®, regardless of the exposure time. Cellular cytotoxicity was found after Lorsban* 48E® and CPF Zamba® treatments for all concentrations and time exposures, estimated by a decrease in the frequency of mature erythrocytes and a concomitant enhanced frequency of erythroblasts in circulating blood. Furthermore, our results demonstrated that Lorsban* 48E® and CPF Zamba® should be considered as CPF-based commercial formulations with marked genotoxic and cytotoxic properties.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Mortality
dc.subject
Micronucleus
dc.subject
Erythrocyte:Erythroblast Ratio
dc.subject
Poeciliidae
dc.subject
Lorsban* 48e®
dc.subject
Chlorpyrifos Zamba®
dc.subject.classification
Otras Ciencias Biológicas
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Chlorpyrifos-based insecticides induced genotoxic and cytotoxic effects in the ten spotted live-bearer fish, Cnesterodon decemmaculatus (Jenyns, 1842)
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-21T16:27:16Z
dc.identifier.eissn
1522-7278
dc.journal.volume
29
dc.journal.number
12
dc.journal.pagination
1390-1398
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Vera Candioti, Josefina. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Soloneski, Sonia Maria Elsa. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Larramendy, Marcelo Luis. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Cátedra de Citología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Environmental Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1002/tox.21869
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/tox.21869/abstract


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