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dc.contributor.author
Magnoni, Leonardo Julián
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dc.contributor.author
Palstra, Arjan P.
dc.contributor.author
Planas, Josep V.
dc.date.available
2017-12-22T19:05:26Z
dc.date.issued
2014-05
dc.identifier.citation
Magnoni, Leonardo Julián; Palstra, Arjan P.; Planas, Josep V.; Fueling the engine: induction of AMP-activated protein kinase in trout skeletal muscle by swimming; Company of Biologists; Journal of Experimental Biology; 217; 5-2014; 1649-1652
dc.identifier.issn
0022-0949
dc.identifier.uri
http://hdl.handle.net/11336/31410
dc.description.abstract
AMP-activated protein kinase (AMPK) is well known to be induced by exercise and to mediate important metabolic changes in the skeletal muscle of mammals. Despite the physiological importance of exercise as a modulator of energy use by locomotory muscle, the regulation of this enzyme by swimming has not been investigated in fish. We found that sustained swimming (40 days at 0.75 body lengths s−1) increased AMPK activity in red and white trout skeletal muscle (3.9- and 2.2-fold, respectively) as well as the expression of AMPK target genes involved in energy use: lipoprotein lipase and citrate synthase in red and white muscle and CPT1β1b and PGC-1α in red muscle. Furthermore, electrical pulse stimulation of cultured trout myotubes increased AMPK activity and glucose uptake (1.9- and 1.2-fold, respectively) in an AMPK-dependent manner. These results suggest that AMPK may play an important mediatory role in the metabolic adaptation to swimming in fish skeletal muscle.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Company of Biologists
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ampk
dc.subject
Skeletal Muscle
dc.subject
Swimming
dc.subject
Fish
dc.subject.classification
Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Fueling the engine: induction of AMP-activated protein kinase in trout skeletal muscle by swimming
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-21T19:58:55Z
dc.journal.volume
217
dc.journal.pagination
1649-1652
dc.journal.pais
Reino Unido
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dc.description.fil
Fil: Magnoni, Leonardo Julián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas ; Argentina
dc.description.fil
Fil: Palstra, Arjan P.. University of Agriculture Wageningen; Países Bajos
dc.description.fil
Fil: Planas, Josep V.. No especifica;
dc.journal.title
Journal of Experimental Biology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://jeb.biologists.org/content/217/10/1649
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1242/jeb.099192
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