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dc.contributor.author
Dellarupe, Andrea
dc.contributor.author
Regidor Cerrillo, Javier
dc.contributor.author
Jimenez Ruiz, Elena
dc.contributor.author
Schares, Gereon
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Unzaga, Juan Manuel
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Venturini, María Cecilia
dc.contributor.author
Ortega Mora, Luis M.
dc.date.available
2017-12-22T19:05:13Z
dc.date.issued
2013-10
dc.identifier.citation
Ortega Mora, Luis M.; Venturini, María Cecilia; Unzaga, Juan Manuel; Schares, Gereon; Jimenez Ruiz, Elena; Regidor Cerrillo, Javier; et al.; Clinical outcome and vertical transmission variability among canine Neospora caninum isolates in a pregnant mouse model of infection; Cambridge University Press; Parasitology; 141; 3; 10-2013; 356-366
dc.identifier.issn
0031-1820
dc.identifier.uri
http://hdl.handle.net/11336/31409
dc.description.abstract
We compared the clinical outcome and vertical transmission of six canine Neospora caninum isolates using a pregnant BALB/c model. Four of the isolates were obtained from oocysts of naturally infected dogs (Nc-Ger2, Nc-Ger3, Nc-Ger6 and Nc-6Arg) and two were from diseased dogs with neurological signs (Nc-Bahia and Nc-Liv). The dams were inoculated with 2×106 tachyzoites of each isolate at day 7 of pregnancy. Morbidity, mortality and the antibody responses were evaluated in both the dams and the offspring, as was parasite transmission to the progeny. The mortality rates varied from 100% in Nc-Bahia and Nc-Liv-infected pups to 19% or less for those infected with the isolates from oocysts. The vertical transmission rates varied from 9 to 53% for N. caninum from oocysts, compared with 100% for the Nc-Liv and Nc-Bahia isolates. All dams showed specific IgG responses against tachyzoite and rNc-GRA7 antigens, confirming Neospora infection. The highest IgG levels were detected in mice inoculated with the Nc-Liv and Nc-Bahia isolates. These results demonstrate marked differences in virulence between the N. caninum isolates obtained from oocysts and neurologically affected dogs. This variability could help us to explain the differences in the outcome of the infection in definitive and intermediate hosts.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Cambridge University Press
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
N. Caninum
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In Vivo
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Vertical Transmission
dc.subject.classification
Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Clinical outcome and vertical transmission variability among canine Neospora caninum isolates in a pregnant mouse model of infection
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-21T19:59:45Z
dc.journal.volume
141
dc.journal.number
3
dc.journal.pagination
356-366
dc.journal.pais
Reino Unido
dc.journal.ciudad
Cambridge
dc.description.fil
Fil: Dellarupe, Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Complutense de Madrid; España. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
dc.description.fil
Fil: Regidor Cerrillo, Javier. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Jimenez Ruiz, Elena. Universidad Complutense de Madrid; España
dc.description.fil
Fil: Schares, Gereon. Friedrich Loeffler Institut; Alemania
dc.description.fil
Fil: Unzaga, Juan Manuel. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina
dc.description.fil
Fil: Venturini, María Cecilia. Universidad Nacional de la Plata. Facultad de Ciencias Veterinarias. Departamento de Epizootiología y Salud Pública. Laboratorio de Inmunoparasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Ortega Mora, Luis M.. Universidad Complutense de Madrid; España
dc.journal.title
Parasitology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1017/S0031182013001479
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.cambridge.org/core/journals/parasitology/article/clinical-outcome-and-vertical-transmission-variability-among-canine-neospora-caninum-isolates-in-a-pregnant-mouse-model-of-infection/952DEFE4FBD93098AD855BD3B408492F


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