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dc.contributor.author
Labombarda, Maria Florencia
dc.contributor.author
Gonzalez, Susana Laura
dc.contributor.author
Gonzalez Deniselle, Maria Claudia
dc.contributor.author
Guennoun, Rachida
dc.contributor.author
Schumacher, Michael
dc.contributor.author
de Nicola, Alejandro Federico
dc.date.available
2017-12-22T02:24:11Z
dc.date.issued
2002-05
dc.identifier.citation
de Nicola, Alejandro Federico; Schumacher, Michael; Guennoun, Rachida; Gonzalez Deniselle, Maria Claudia; Gonzalez, Susana Laura; Labombarda, Maria Florencia; et al.; Cellular basis for Progesterone neuroprotection in the injured spinal cord; Mary Ann Liebert; Journal of Neurotrauma; 19; 3; 5-2002; 343-355
dc.identifier.issn
0897-7151
dc.identifier.uri
http://hdl.handle.net/11336/31332
dc.description.abstract
Progesterone (PROG) exerts beneficial and neuroprotective effects in the injured central and peripheral nervous system. In the present work, we examine PROG effects on three measures of neuronal function under negative regulation (choline acetyltransferase [ChAT] and Na,K-ATPase) or stimulated (growth-associated protein [GAP-43]) after acute spinal cord transection injury  in rats.<br />As expected, spinal cord injury reduced ChAT immunostaining intensity of ventral horn neurons. A 3-day course of intensive PROG treatment of transected rats restored ChAT immunoreactivity, as assessed by frequency histograms that recorded shifts from predominantly light neuronal staining to medium, dark or intense staining typical of control rats. Transection also reduced the expression of the mRNA for the a3 catalytic and b1 regulatory subunits of neuronal Na,K-ATPase, whereas PROG treatment restored both subunit mRNA to normal levels. Additionally, the upregulation observed for GAP-43 mRNA in ventral horn neurons in spinal cord?transected rats, was further enhanced by PROG administration. In no case did PROG modify ChAT immunoreactivity, Na,K-ATPase subunit mRNA or GAP-43 mRNA in control, sham-operated rats. Further, the PROG mediated effects on these three markers were observed in large, presumably Lamina IX motoneurons, as well as in smaller neurons measuring approximately ,500 m2. Overall, the stimulatory effects of PROG on ChAT appears to replenish acetylcholine, with its  stimulatory effects on Na,K-ATPase seems capable of restoring membrane potential, ion transport and nutrient uptake. PROG effects on GAP-43 also appear to accelerate reparative responses to injury. As the cellular basis for PROG neuroprotection becomes better understood it may prove of therapeutic benefit to spinal cord injury patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Mary Ann Liebert
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Spinal Cord Injury
dc.subject
Progesterone
dc.subject
Neuroprotection
dc.subject
Chat
dc.subject.classification
Neurociencias
dc.subject.classification
Medicina Básica
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Cellular basis for Progesterone neuroprotection in the injured spinal cord
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-04T17:55:12Z
dc.identifier.eissn
1557-9042
dc.journal.volume
19
dc.journal.number
3
dc.journal.pagination
343-355
dc.journal.pais
Estados Unidos
dc.journal.ciudad
New York
dc.description.fil
Fil: Labombarda, Maria Florencia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Gonzalez, Susana Laura. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Gonzalez Deniselle, Maria Claudia. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Guennoun, Rachida. Inserm; Francia
dc.description.fil
Fil: Schumacher, Michael. Inserm; Francia
dc.description.fil
Fil: de Nicola, Alejandro Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Bioquímica Humana; Argentina. Instituto Universidad de la Fundación "Héctor Barceló"; Argentina
dc.journal.title
Journal of Neurotrauma
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://online.liebertpub.com/doi/abs/10.1089/089771502753594918
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1089/089771502753594918
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/pmid/https://www.ncbi.nlm.nih.gov/pubmed/11939502


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