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dc.contributor.author
Rocha, Ana
dc.contributor.author
Iñiguez, German
dc.contributor.author
Godoy, Claudia
dc.contributor.author
Gaete, Ximena
dc.contributor.author
Lopez, Patricia
dc.contributor.author
Loreti, Rosana Nazareth
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dc.contributor.author
Campo, Stella Maris
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dc.contributor.author
Rey, Rodolfo Alberto
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dc.contributor.author
Codner, Ethel
dc.date.available
2015-12-21T17:50:59Z
dc.date.issued
2013-09
dc.identifier.citation
Rocha, Ana; Iñiguez, German; Godoy, Claudia; Gaete, Ximena; Lopez, Patricia; et al.; Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): Absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty; Wiley Blackwell Publishing, Inc; Pediatric Diabetes; 15; 3; 9-2013; 198-205
dc.identifier.issn
1399-543X
dc.identifier.uri
http://hdl.handle.net/11336/3109
dc.description.abstract
Aim: Conflicting results regarding testicular function in adults with type 1 diabetes (T1D) have been reported, but little is known about Leydig and Sertoli cell function during puberty in boys treated with multiple daily insulin doses. Our aim was to assess testicular function in boys with T1D. Methods: Pubertal boys with T1D (n=71) and healthy control boys (Control group; n=104) who were 10-18years were studied. Both groups were matched by pubertal stage, age, and BMI. Total testosterone (TT), calculated free testosterone (cfT), SHBG, inhibin B, AMH, and gonadotropin levels were determined. Results: At the beginning of puberty, the T1D group had higher levels of SHBG (p=0.003) and similar androgen levels than the Control group. At the end of puberty, higher TT, and cfT were observed in T1D compared to the Control group (p<0.01 and p<0.001, respectively). Gonadotropins and AMH were similar in both groups. Regression analysis showed that T1D was a significant factor, even after adjusting for Tanner stage and BMI-SDS, affecting TT, cFT, and SHBG levels. BMI-SDS was a significant factor affecting TT and SHBG levels. Higher HbA1c had a negative effect on total testosterone and cFT and a positive effect on SHBG levels in T1D boys. Conclusion: Adolescents with T1D do not exhibit hypogonadism, as shown by normal gonadotropin, testosterone, inhibin B, and AMH levels. However, in T1D boys, HbA1c and BMI-SDS had a negative association with testosterone levels. Elevated testosterone levels are observed during late puberty, which were not present earlier.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Complication
dc.subject
Diabetes Mellitus Type 1
dc.subject
Puberty
dc.subject
Testosterone
dc.subject.classification
Endocrinología y Metabolismo
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Testicular function during adolescence in boys with type 1 diabetes mellitus (T1D): Absence of hypogonadism and differences in endocrine profile at the beginning and end of puberty
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
15
dc.journal.number
3
dc.journal.pagination
198-205
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Rocha, Ana. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran. Instituto de Investigaciones Materno Infantil; Chile
dc.description.fil
Fil: Iñiguez, German. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran. Instituto de Investigaciones Materno Infantil; Chile
dc.description.fil
Fil: Godoy, Claudia. Hospital Sótero del Río. Unidad de Endocrinología; Chile
dc.description.fil
Fil: Gaete, Ximena. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran. Instituto de Investigaciones Materno Infantil; Chile
dc.description.fil
Fil: Lopez, Patricia. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran. Instituto de Investigaciones Materno Infantil; Chile
dc.description.fil
Fil: Loreti, Rosana Nazareth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Campo, Stella Maris. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Rey, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas; Argentina
dc.description.fil
Fil: Codner, Ethel. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran. Instituto de Investigaciones Materno Infantil; Chile
dc.journal.title
Pediatric Diabetes
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1111/pedi.12078
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/pedi.12078
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