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dc.contributor.author
Curic, S.
dc.contributor.author
Wu, Y.
dc.contributor.author
Shan, B.
dc.contributor.author
Schaaf, C.
dc.contributor.author
Utpadel, D.
dc.contributor.author
Lange, M.
dc.contributor.author
Kuhlen, D.
dc.contributor.author
Perone, Marcelo Javier
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dc.contributor.author
Arzt, Eduardo Simon
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dc.contributor.author
Stalla, G. K.
dc.contributor.author
Renner, U.
dc.date.available
2015-12-21T17:45:36Z
dc.date.issued
2013-05-11
dc.identifier.citation
Curic, S.; Wu, Y.; Shan, B.; Schaaf, C.; Utpadel, D.; et al.; Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas; Springer; Journal of Neuro-oncology; 113; 3; 11-5-2013; 385-396
dc.identifier.issn
0167-594X
dc.identifier.uri
http://hdl.handle.net/11336/3102
dc.description.abstract
Meningiomas, the most frequent benign intracranial and intraspinal types of tumors are normally removed by surgery. Complications can occur when the tumor is critically localized and cannot be completely removed or when comorbidities of the mostly elder patients increase the general surgical risk. Thus, alternate medical treatment concepts for the therapy of meningiomas would be desirable. Curcumin, the active ingredient of the spice plant Curcuma longa has shown anti-tumorigenic actions in many different types of tumors and therefore, its effect on growth and apoptosis of meningioma cells was studied in the present paper. In vitro, treatment of the human Ben-Men-1 meningioma cell line and of a series of 21 primary human meningioma cell cultures with curcumin (1-20 μM) strongly reduced the proliferation in all cases in a dose dependent manner. Cell cycle analysis by fluorescence-activated cell sorting showed growth arrest at G2/M phase, which was confirmed by demonstrating the corresponding modulation of proteins involved in G2/M arrest by immunoblotting and/or confocal laser microscopy. High dosages (20, 50 μM) of curcumin induced a significant increase of apoptosis in Ben-Men-1 and primary meningioma cell cultures as demonstrated by morphological changes of cell nuclei, DNA fragmentation, translocation of cell membrane associated phosphatidyl serine and the induction of apoptotic-acting cleaved caspase-3. Our results suggest that the multi-targeting drug curcumin has potent anti-tumorigenic actions in meningioma cells and might therefore be a putative candidate for the pharmacological treatment of meningiomas.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Meningioma
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Curcumin
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Proliferation
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Apoptosis
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G2/M Phase Cell Cycle Arrest
dc.subject.classification
Oncología
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.subject.classification
Neurología Clínica
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dc.subject.classification
Medicina Clínica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Curcumin acts anti-proliferative and pro-apoptotic in human meningiomas
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
113
dc.journal.number
3
dc.journal.pagination
385-396
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlín
dc.description.fil
Fil: Curic, S.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
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Fil: Wu, Y.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.description.fil
Fil: Shan, B.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.description.fil
Fil: Schaaf, C.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.description.fil
Fil: Utpadel, D.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.description.fil
Fil: Lange, M.. Clinic Villingen Schwenningen. Neurosurgical Department; Alemania
dc.description.fil
Fil: Kuhlen, D.. Technical University Munich. Neurosurgical Clinic; Alemania
dc.description.fil
Fil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina
dc.description.fil
Fil: Arzt, Eduardo Simon. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
dc.description.fil
Fil: Stalla, G. K.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.description.fil
Fil: Renner, U.. Max Planck Institute of Psychiatry. Clinical Neuroendocrinology Group; Alemania
dc.journal.title
Journal of Neuro-oncology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs11060-013-1148-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11060-013-1148-9
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