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dc.contributor.author
Peng, Yu Hao  
dc.contributor.author
Heintz, Ryan  
dc.contributor.author
Wang, Zhuo  
dc.contributor.author
Guo,Yumei  
dc.contributor.author
Myers, Kalisa G.  
dc.contributor.author
Scremin, Oscar Umberto  
dc.contributor.author
Maarek, Jean Michel  
dc.contributor.author
Holschneider, Daniel P.  
dc.date.available
2017-12-19T17:48:04Z  
dc.date.issued
2014-12  
dc.identifier.citation
Holschneider, Daniel P.; Maarek, Jean Michel; Scremin, Oscar Umberto; Myers, Kalisa G.; Guo,Yumei; Wang, Zhuo; et al.; exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain; Benjamin-Cummings Publishing Company; Frontiers in Physics; 2; 72; 12-2014  
dc.identifier.issn
0429-7725  
dc.identifier.uri
http://hdl.handle.net/11336/31027  
dc.description.abstract
Current rodent connectome projects are revealing brain structural connectivity with unprecedented resolution and completeness. How subregional structural connectivity relates to subregional functional interactions is an emerging research topic. We describe a method for standardized, mesoscopic-level data sampling from autoradiographic coronal sections of the rat brain, and for correlation-based analysis and intuitive display of cortico-cortical functional connectivity (FC) on a flattened cortical map. A graphic user interface “Cx-2D” allows for the display of significant correlations of individual regions-of-interest, as well as graph theoretical metrics across the cortex. Cx-2D was tested on an autoradiographic data set of cerebral blood flow (CBF) of rats that had undergone bilateral striatal lesions, followed by 4 weeks of aerobic exercise training or no exercise. Effects of lesioning and exercise on cortico-cortical FC were examined during a locomotor challenge in this rat model of Parkinsonism. Subregional FC analysis revealed a rich functional reorganization of the brain in response to lesioning and exercise that was not apparent in a standard analysis focused on CBF of isolated brain regions. Lesioned rats showed diminished degree centrality of lateral primary motor cortex, as well as neighboring somatosensory cortex—changes that were substantially reversed in lesioned rats following exercise training. Seed analysis revealed that exercise increased positive correlations in motor and somatosensory cortex, with little effect in non-sensorimotor regions such as visual, auditory, and piriform cortex. The current analysis revealed that exercise partially reinstated sensorimotor FC lost following dopaminergic deafferentation. Cx-2D allows for standardized data sampling from images of brain slices, as well as analysis and display of cortico-cortical FC in the rat cerebral cortex with potential applications in a variety of autoradiographic and histologic studies  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Benjamin-Cummings Publishing Company  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
Cerebral Cortex  
dc.subject
Functional Connectivity  
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Brain Mapping  
dc.subject
Exercise  
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Motor Training  
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Parkinson’S Disease  
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Dopamine  
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Software  
dc.subject.classification
Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
exercise training reinstates cortico-cortical sensorimotor functional connectivity following striatal lesioning: development and application of a subregional-level analytic toolbox for perfusion autoradiographs of the rat brain  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-12-12T18:21:11Z  
dc.journal.volume
2  
dc.journal.number
72  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
California  
dc.description.fil
Fil: Peng, Yu Hao. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Heintz, Ryan. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Wang, Zhuo. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Guo,Yumei. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Myers, Kalisa G.. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Scremin, Oscar Umberto. Veterans Affairs Greater Los Angeles Healthcare System. Los Angeles; Estados Unidos. University of California at Los Angeles; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Maarek, Jean Michel. University of Southern California; Estados Unidos  
dc.description.fil
Fil: Holschneider, Daniel P.. University of Southern California; Estados Unidos  
dc.journal.title
Frontiers in Physics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3389/fphy.2014.00072  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fphy.2014.00072/full