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Artículo

Two different vestigial like 4 genes are differentially expressed during Xenopus laevis development

Barrionuevo, María Guadalupe del ValleIcon ; Aybar, Manuel JavierIcon ; Tríbulo, CelesteIcon
Fecha de publicación: 10/2014
Editorial: U B C Press
Revista: International Journal Of Developmental Biology
ISSN: 0214-6282
e-ISSN: 1696-3547
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Biológicas

Resumen

The vestigial gene (vg) was first characterized in Drosophila and several homologues were identified in vertebrates and called vestigial like 1-4 (vgll1-4). Vgll proteins interact with the transcription factors TEF-1 and MEF-2 through a conserved region called TONDU (TDU). Vgll4s are characterized by two tandem TDU domains which differentiate them from other members of the vestigial family. In Xenopus two genes were identified as vgll4. Our bioinformatic analysis demonstrated that these two genes are paralogues and must be named differently. We designated them as vgll4 and vgll4l. In situ hybridization analysis revealed that the expression of these two genes is rather different. At gastrula stage, both were expressed in the animal pole. However, at neurula stage, vgll4 was mainly expressed in the neural plate and neural folds, while vgll4l prevailed in the neural folds and epidermis. From the advanced neurula stage onward, expression of both genes was strongly enhanced in neural tissues, anterior neural plate, migrating neural crest, optic and otic vesicles. Nevertheless, there were some differences: vgll4 presented somite expression and vgll4l was localized at the skin and notochord. Our results demonstrate that Xenopus has two orthologues of the vgll4 gene, vgll4 and vgll4l with differential expression in Xenopus embryos and they may well have different roles during development.
Palabras clave: Epidermis , Vgl4a , Vgl4b , Tondu , Vestigial
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/30820
DOI: http://dx.doi.org/10.1387/ijdb.130353ct
URL: http://www.ijdb.ehu.es/web/paper.php?doi=130353ct
Colecciones
Articulos(INSIBIO)
Articulos de INST.SUP.DE INVEST.BIOLOGICAS
Citación
Barrionuevo, María Guadalupe del Valle; Tríbulo, Celeste; Aybar, Manuel Javier; Two different vestigial like 4 genes are differentially expressed during Xenopus laevis development; U B C Press; International Journal Of Developmental Biology; 58; 10-2014; 369-377
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