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dc.contributor.author
Mariano, Rodolfo Nicolás
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Alberti, Diego Javier
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Cutrin, Juan Carlos
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Geninatti Crich, Simonetta
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Aime, Silvio
dc.date.available
2017-12-15T17:59:20Z
dc.date.issued
2014-09
dc.identifier.citation
Mariano, Rodolfo Nicolás; Alberti, Diego Javier; Cutrin, Juan Carlos; Geninatti Crich, Simonetta; Aime, Silvio; Design of PLGA Based Nanoparticles for Imaging Guided Applications; American Chemical Society; Molecular Pharmaceutics; 11; 11; 9-2014; 4100-4106
dc.identifier.issn
1543-8384
dc.identifier.uri
http://hdl.handle.net/11336/30786
dc.description.abstract
An amphiphilic Gd(III) complex has been efficiently loaded in polylactic-co-glycolic acid nanoparticles (PLGA-NPs) to yield a novel, high sensitive magnetic resonance imaging (MRI) contrast agent for imaging guided drug delivery applications. As the Gd(III) complex is soluble in organic solvents, the nanoparticles were prepared as oil/water emulsions. PLGA-NPs were stable, in buffer, for more than 1 week without any release of the incorporated agents. The millimolar relaxivity of the Gd(III) complex incorporated in the particles (140 nm diameter) was of 21.7 mM(-1) s(-1) at 21.5 MHz, a value that is about 5 times higher than that observed with the commercially available contrast agents used in clinic. The relaxometric efficiency of these particles resulted inversely proportional to the particle size measured by dynamic light scattering. The high stability and sensitivity of PLGA-NPs allowed their accumulation in vivo in murine melanoma xenograft as shown in the corresponding MR images. Once loaded with drug and contrast agents, PLGA nanoparticles can be proposed as efficient theranostic MRI agents.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Chemical Society
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Gd(Iii) Complexes
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Mri
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Contrast Agents
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Imaging Guided Therapy
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Plga
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Nanoparticles
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Design of PLGA Based Nanoparticles for Imaging Guided Applications
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-15T14:56:42Z
dc.journal.volume
11
dc.journal.number
11
dc.journal.pagination
4100-4106
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington DC
dc.description.fil
Fil: Mariano, Rodolfo Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
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Fil: Alberti, Diego. Università di Torino; Italia
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Fil: Cutrin, Juan Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
dc.description.fil
Fil: Geninatti Crich, Simonetta. Università di Torino; Italia
dc.description.fil
Fil: Aime, Silvio. Università di Torino; Italia
dc.journal.title
Molecular Pharmaceutics
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pubs.acs.org/doi/abs/10.1021/mp5002747
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1021/mp5002747
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