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dc.contributor.author
Finamor, Isabela A.
dc.contributor.author
Ourique, Giovana M.
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Pês, Tanise S.
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Saccol, Etiane M. H.
dc.contributor.author
Bressan, Caroline A.
dc.contributor.author
Scheid, Taína
dc.contributor.author
Baldisserotto, Bernardo
dc.contributor.author
Llesuy, Susana Francisca
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dc.contributor.author
Partata, Wânia A.
dc.contributor.author
Pavanato, Maria A.
dc.date.available
2017-12-15T17:34:36Z
dc.date.issued
2014-09
dc.identifier.citation
Pavanato, Maria A.; Partata, Wânia A.; Llesuy, Susana Francisca; Baldisserotto, Bernardo; Scheid, Taína; Bressan, Caroline A.; et al.; The Protective Effect of N-Acetylcysteine on Oxidative Stress in the Brain Caused by the Long-Term Intake of Aspartame by Rats; Springer; Neurochemical Research; 39; 9; 9-2014; 1681-1690
dc.identifier.issn
0364-3190
dc.identifier.uri
http://hdl.handle.net/11336/30773
dc.description.abstract
Long-term intake of aspartame at the acceptable daily dose causes oxidative stress in rodent brain mainly due to the dysregulation of glutathione (GSH) homeostasis. N-Acetylcysteine provides the cysteine that is required for the production of GSH, being effective in treating disorders associated with oxidative stress. We investigated the effects of N-acetylcysteine treatment (150 mg kg(-1), i.p.) on oxidative stress biomarkers in rat brain after chronic aspartame administration by gavage (40 mg kg(-1)). N-Acetylcysteine led to a reduction in the thiobarbituric acid reactive substances, lipid hydroperoxides, and carbonyl protein levels, which were increased due to aspartame administration. N-Acetylcysteine also resulted in an elevation of superoxide dismutase, glutathione peroxidase, glutathione reductase activities, as well as non-protein thiols, and total reactive antioxidant potential levels, which were decreased after aspartame exposure. However, N-acetylcysteine was unable to reduce serum glucose levels, which were increased as a result of aspartame administration. Furthermore, catalase and glutathione S-transferase, whose activities were reduced due to aspartame treatment, remained decreased even after N-acetylcysteine exposure. In conclusion, N-acetylcysteine treatment may exert a protective effect against the oxidative damage in the brain, which was caused by the long-term consumption of the acceptable daily dose of aspartame by rats.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
N-Acetylcysteine Protective
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Aspartame
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Brain
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Oxidative Damage
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Glutathione
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Protective
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Otras Ciencias Biológicas
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
The Protective Effect of N-Acetylcysteine on Oxidative Stress in the Brain Caused by the Long-Term Intake of Aspartame by Rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2017-12-15T14:55:41Z
dc.identifier.eissn
1573-6903
dc.journal.volume
39
dc.journal.number
9
dc.journal.pagination
1681-1690
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Finamor, Isabela A.. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Ourique, Giovana M.. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Pês, Tanise S.. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Saccol, Etiane M. H.. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Bressan, Caroline A.. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Scheid, Taína. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Baldisserotto, Bernardo. Universidade Federal de Santa Maria; Brasil
dc.description.fil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Bioquímica y Medicina Molecular; Argentina
dc.description.fil
Fil: Partata, Wânia A.. Universidade Federal do Rio Grande do Sul; Brasil
dc.description.fil
Fil: Pavanato, Maria A.. Universidade Federal do Rio Grande do Sul; Brasil
dc.journal.title
Neurochemical Research
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11064-014-1360-9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11064-014-1360-9
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