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dc.contributor.author
Caltana, Laura Romina  
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Rutolo, Damián  
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Nieto, Maria Luisa  
dc.contributor.author
Brusco, Herminia Alicia  
dc.date.available
2017-12-15T15:27:42Z  
dc.date.issued
2014-10  
dc.identifier.citation
Caltana, Laura Romina; Rutolo, Damián; Nieto, Maria Luisa; Brusco, Herminia Alicia; Further evidence for the neuroprotective role of oleanolic acid in a model of focal brain hypoxia in rats; Elsevier; Neurochemistry International; 79; 10-2014; 79-87  
dc.identifier.issn
0197-0186  
dc.identifier.uri
http://hdl.handle.net/11336/30747  
dc.description.abstract
Ischemic brain injury is a dynamic process involving oxidative stress, inflammation, cell death and the activation of endogenous adaptive and regenerative mechanisms depending on the activation of transcription factors such as hypoxia-inducible factor 1-alpha. Accordingly, we have previously described a new focal hypoxia model by direct intracerebral cobalt chloride injection. In turn, oleanolic acid, a plant-derived triterpenoid, has been extensively used in Asian countries for its anti-inflammatory and anti-tumor properties. A variety of novel pharmacological effects have been attributed to this triterpenoid, including beneficial effects on neurodegenerative disorders - including experimental autoimmune encephalomyelitis - due to its immunomodulatory activities at systemic level, as well as within the central nervous system. In this context, we hypothesize that this triterpenoid may be capable of exerting neuroprotective effects in ischemic brain, suppressing glial activities that contribute to neurotoxicity while promoting those that support neuronal survival. In order to test this hypothesis, we used the intraperitoneal administration of oleanoic acid in adult rats for seven days previous to focal cortical hypoxia induced by cobalt chloride brain injection. We analyzed the neuroprotective effect of oleanoic acid from a morphological point of view, focusing on neuronal survival and glial reaction.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/  
dc.subject
Ischemia  
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Oleanoic Acid  
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Neuroprotection  
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Neuronal Death  
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Brain Injury  
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Neurociencias  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Further evidence for the neuroprotective role of oleanolic acid in a model of focal brain hypoxia in rats  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2017-12-15T14:56:08Z  
dc.journal.volume
79  
dc.journal.pagination
79-87  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Ámsterdam  
dc.description.fil
Fil: Caltana, Laura Romina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
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Fil: Rutolo, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
dc.description.fil
Fil: Nieto, Maria Luisa. Universidad de Valladolid; España. Consejo Superior de Investigaciones Científicas; España  
dc.description.fil
Fil: Brusco, Herminia Alicia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia ; Argentina  
dc.journal.title
Neurochemistry International  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0197018614002150  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.neuint.2014.09.011