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Artículo

Bromocryptine restores angiotensin II response in pituitary hyperplasia

González Iglesias, A.; Diaz, Graciela SusanaIcon ; Piroli, Gerardo GustavoIcon ; Achával Zaia, R.; de Nicola, Alejandro FedericoIcon ; Libertun, CarlosIcon ; Becu, DamasiaIcon
Fecha de publicación: 2000
Editorial: Elsevier Ireland
Revista: Molecular and Cellular Endocrinology
ISSN: 0303-7207
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Fisiología

Resumen

In estrogen-induced pituitary hyperplasia AII-evoked prolactin release is decreased and the octapeptide does not generate a spike elevation in [Ca(2+)](i) in vitro. We studied whether or not bromocriptine could restore AII response in diethylstilbestrol treated rats. Co-administration of bromocriptine resulted in involution of pituitary size and lowering of serum prolactin. In vitro, prolactin release per cell was reduced in the hyperplastic group, and levels were not significantly increased by in vivo bromocriptine treatment. Immunocytochemical analysis revealed that hyperplastic pituitaries contained fewer prolactin granules than control pituitaries, and that bromocriptine, did not increase prolactin storage. Nevertheless, in this group, prolactin response to AII increased, and AII evoked a consistent spike in [Ca(2+)](i), albeit lower than in the control group. Such spike was abolished by thapsigargin, and not by removal of extracellular calcium or by K(+), indicating that it was mainly dependent on intracellular calcium stores, as in normal cells. We conclude that bromocriptine treatment partially restores AII response in the hyperplastic pituitary.
Palabras clave: Endocrinology , Angiotensin , Calcium , Hyperplasia
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/30716
URL: http://www.sciencedirect.com/science/article/pii/S0303720700002707?via%3Dihub
DOI: http://dx.doi.org/10.1016/S0303-7207(00)00270-7
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Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
González Iglesias, A.; Diaz, Graciela Susana; Piroli, Gerardo Gustavo; Achával Zaia, R.; de Nicola, Alejandro Federico; et al.; Bromocryptine restores angiotensin II response in pituitary hyperplasia; Elsevier Ireland; Molecular and Cellular Endocrinology; 165; 1-2; 2000; 67-74
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